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Title: Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma

Abstract

The effect of W. somnifera on glycosaminoglycan synthesis in the granulation tissue of carrageenin-induced air pouch granuloma was studied. W. somnifera was shown to exert significant inhibitory effect on incorporation of /sup 35/S into the granulation tissue. The uncoupling effect on oxidative phosphorylation (ADP/O ratio reduction) was also observed in the mitochondria of granulation tissue. Further, Mg/sup 2 +/ dependent ATPase activity was found to be influenced by W. somnifera. W. somnifera also reduced the succinate dehydrogenase enzyme activity in the mitochondria of granulation tissue.

Authors:
;
Publication Date:
Research Org.:
Tamil Univ. (India)
OSTI Identifier:
5298604
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochem. Med. Metab. Biol.; (United States); Journal Volume: 38:3
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ATP-ASE; ENZYME ACTIVITY; GLUCOPROTEINS; BIOSYNTHESIS; OXIDOREDUCTASES; SHRUBS; BIOLOGICAL EFFECTS; ADP; GRANULOMAS; HYDROCORTISONE; INHIBITION; MITOCHONDRIA; PHOSPHORYLATION; RATS; SULFATES; SULFUR 35; ACID ANHYDRASES; ADRENAL HORMONES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOHYDRATES; CELL CONSTITUENTS; CHEMICAL REACTIONS; CORTICOSTEROIDS; DAYS LIVING RADIOISOTOPES; DISEASES; ENZYMES; EVEN-ODD NUCLEI; GLUCOCORTICOIDS; HORMONES; HYDROLASES; HYDROXY COMPOUNDS; ISOTOPES; KETONES; LIGHT NUCLEI; MAMMALS; NEOPLASMS; NUCLEI; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANOIDS; OXYGEN COMPOUNDS; PHOSPHOHYDROLASES; PLANTS; PREGNANES; PROTEINS; RADIOISOTOPES; RODENTS; SACCHARIDES; STEROID HORMONES; STEROIDS; SULFUR COMPOUNDS; SULFUR ISOTOPES; SYNTHESIS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Begum, V.H., and Sadique, J.. Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma. United States: N. p., 1987. Web. doi:10.1016/0885-4505(87)90091-0.
Begum, V.H., & Sadique, J.. Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma. United States. doi:10.1016/0885-4505(87)90091-0.
Begum, V.H., and Sadique, J.. 1987. "Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma". United States. doi:10.1016/0885-4505(87)90091-0.
@article{osti_5298604,
title = {Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma},
author = {Begum, V.H. and Sadique, J.},
abstractNote = {The effect of W. somnifera on glycosaminoglycan synthesis in the granulation tissue of carrageenin-induced air pouch granuloma was studied. W. somnifera was shown to exert significant inhibitory effect on incorporation of /sup 35/S into the granulation tissue. The uncoupling effect on oxidative phosphorylation (ADP/O ratio reduction) was also observed in the mitochondria of granulation tissue. Further, Mg/sup 2 +/ dependent ATPase activity was found to be influenced by W. somnifera. W. somnifera also reduced the succinate dehydrogenase enzyme activity in the mitochondria of granulation tissue.},
doi = {10.1016/0885-4505(87)90091-0},
journal = {Biochem. Med. Metab. Biol.; (United States)},
number = ,
volume = 38:3,
place = {United States},
year = 1987,
month =
}
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