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Title: Effects of feeding selenium deficient diets to rhesus monkeys (Macaca Mulatta)

Abstract

Pregnant rhesus monkeys (Macaca mulatta) were fed either selenium (Se) deficient or Se supplemented diets with adequate vitamin E. Except for some cardiac irregularities in the first babies born to these females, no physiological disorders due to Se deficiency were seen in a subsequent offspring. Plasma and erythrocyte glutathione peroxidase activities and blood Se levels increased in the Se supplemented monkeys but decreased in the deficient ones. The data indicated that hair Se levels reflect long term exposure to this element. In a very preliminary experiment, evidence was obtained to indicate that dietary protein deficiency along with Se deficiency will generate cardiomyopathic lesions characteristic of Se deficiency. It is hypothesized that, in addition to Se deficiency, another dietary deficiency (or abnormality) is necessary to produce Se deficiency lesions in higher primates. Higher glutathione transferase (or non-Se glutathione peroxidase) activity in tissues of rhesus monkeys may account for this resistance.

Authors:
; ;
Publication Date:
Research Org.:
Oregon State Univ., Corvallis (USA)
OSTI Identifier:
5284636
Resource Type:
Journal Article
Journal Name:
J. Am. Coll. Nutr.; (United States)
Additional Journal Information:
Journal Volume: 7:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PEROXIDASES; ENZYME ACTIVITY; SELENIUM; NUTRITIONAL DEFICIENCY; TOXICITY; ERYTHROCYTES; HAIR; LIVER; MILK; MONKEYS; PREGNANCY; VITAMIN E; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; DIGESTIVE SYSTEM; ELEMENTS; ENZYMES; FOOD; GLANDS; MAMMALS; MATERIALS; ORGANS; OXIDOREDUCTASES; PRIMATES; SEMIMETALS; SKIN; VERTEBRATES; VITAMINS; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Butler, J A, Whanger, P D, and Patton, N M. Effects of feeding selenium deficient diets to rhesus monkeys (Macaca Mulatta). United States: N. p., 1988. Web. doi:10.1080/07315724.1988.10720219.
Butler, J A, Whanger, P D, & Patton, N M. Effects of feeding selenium deficient diets to rhesus monkeys (Macaca Mulatta). United States. doi:10.1080/07315724.1988.10720219.
Butler, J A, Whanger, P D, and Patton, N M. Mon . "Effects of feeding selenium deficient diets to rhesus monkeys (Macaca Mulatta)". United States. doi:10.1080/07315724.1988.10720219.
@article{osti_5284636,
title = {Effects of feeding selenium deficient diets to rhesus monkeys (Macaca Mulatta)},
author = {Butler, J A and Whanger, P D and Patton, N M},
abstractNote = {Pregnant rhesus monkeys (Macaca mulatta) were fed either selenium (Se) deficient or Se supplemented diets with adequate vitamin E. Except for some cardiac irregularities in the first babies born to these females, no physiological disorders due to Se deficiency were seen in a subsequent offspring. Plasma and erythrocyte glutathione peroxidase activities and blood Se levels increased in the Se supplemented monkeys but decreased in the deficient ones. The data indicated that hair Se levels reflect long term exposure to this element. In a very preliminary experiment, evidence was obtained to indicate that dietary protein deficiency along with Se deficiency will generate cardiomyopathic lesions characteristic of Se deficiency. It is hypothesized that, in addition to Se deficiency, another dietary deficiency (or abnormality) is necessary to produce Se deficiency lesions in higher primates. Higher glutathione transferase (or non-Se glutathione peroxidase) activity in tissues of rhesus monkeys may account for this resistance.},
doi = {10.1080/07315724.1988.10720219},
journal = {J. Am. Coll. Nutr.; (United States)},
number = ,
volume = 7:1,
place = {United States},
year = {1988},
month = {2}
}