Piperazine-induced occupational asthma
Asthmatic reactions were studied among some 130 factory workers who handled amines and other chemicals. Among present employees, we found 15 cases of asthma associated with occupational exposure to chemicals; among former employees there were at least 18. The inducing agent was judged to be piperazine in 29 persons and ethylenediamine (EDA) in three. The asthma was of the late or dual type; immediate reactions alone were to seen. No one had attacks of asthma before employment, and atopic subjects were not preferentially affected. Routine spirometry revealed airway obstruction in fewer than half of the recent cases. Tests of nonspecific bronchial reactivity with methacholine in six subjects with recent asthma showed hyperactivity in five, while tow subjects with earlier asthma did not have hyperactivity. Bronchial provocation tests with piperazine in one subject were positive both in the factory and in the laboratory. The level of piperazine was 1.2 mg/m3 time-weighted average (TWA) in a work place associated with induction of the asthmatic state, and 0.3 mg/m3 in a place connected with attacks in ''sensitized'' subjects.
- Research Organization:
- Department of Occupational Medicine University Hospital, Lund, Sweden
- OSTI ID:
- 5282243
- Journal Information:
- JOM, J. Occup. Med.; (United States), Vol. 24:3
- Country of Publication:
- United States
- Language:
- English
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PIPERAZINES
BIOLOGICAL EFFECTS
ASTHMA
BRONCHI
INDOOR AIR POLLUTION
OCCUPATIONAL DISEASES
PERSONNEL
AIR POLLUTION
AZINES
DISEASES
HETEROCYCLIC COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POLLUTION
PYRAZINES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)