Dose-time relationships for post-irradiation cutaneous telangiectasia
Abstract
Seventy-five patients who had received electron beam radiation a year or more previously were studied. The irradiated skin portals were photographed and late reactions graded in terms of the number and severity of telangiectatic lesions observed. The skin dose, number of fractions, overall treatment time and irradiated volume were recorded in each case. A Strandqvist-type iso-effect line was derived for this response. A multi-probit search program also was used to derive best-fitting cell population kinetic parameters for the same data. From these parameters a comprehensive iso-effect table could be computed for a wide range of treatment schedules including daily treatment as well as fractionation at shorter and longer intervals; this provided a useful set of normal tissue tolerance limits for late effects.
- Authors:
- Publication Date:
- Research Org.:
- Michael Reese Medical Center, Chicago
- OSTI Identifier:
- 5276081
- Resource Type:
- Journal Article
- Journal Name:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States)
- Additional Journal Information:
- Journal Volume: 2:5/6
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RADIOTHERAPY; SIDE EFFECTS; SKIN; RADIATION INJURIES; ELECTRON BEAMS; FRACTIONATED IRRADIATION; PATIENTS; TEMPORAL DOSE DISTRIBUTIONS; BEAMS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; INJURIES; IRRADIATION; LEPTON BEAMS; MEDICINE; NUCLEAR MEDICINE; ORGANS; PARTICLE BEAMS; RADIATION DOSE DISTRIBUTIONS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man
Citation Formats
Cohen, L, and Ubaldi, S E. Dose-time relationships for post-irradiation cutaneous telangiectasia. United States: N. p., 1977.
Web. doi:10.1016/0360-3016(77)90152-3.
Cohen, L, & Ubaldi, S E. Dose-time relationships for post-irradiation cutaneous telangiectasia. United States. https://doi.org/10.1016/0360-3016(77)90152-3
Cohen, L, and Ubaldi, S E. 1977.
"Dose-time relationships for post-irradiation cutaneous telangiectasia". United States. https://doi.org/10.1016/0360-3016(77)90152-3.
@article{osti_5276081,
title = {Dose-time relationships for post-irradiation cutaneous telangiectasia},
author = {Cohen, L and Ubaldi, S E},
abstractNote = {Seventy-five patients who had received electron beam radiation a year or more previously were studied. The irradiated skin portals were photographed and late reactions graded in terms of the number and severity of telangiectatic lesions observed. The skin dose, number of fractions, overall treatment time and irradiated volume were recorded in each case. A Strandqvist-type iso-effect line was derived for this response. A multi-probit search program also was used to derive best-fitting cell population kinetic parameters for the same data. From these parameters a comprehensive iso-effect table could be computed for a wide range of treatment schedules including daily treatment as well as fractionation at shorter and longer intervals; this provided a useful set of normal tissue tolerance limits for late effects.},
doi = {10.1016/0360-3016(77)90152-3},
url = {https://www.osti.gov/biblio/5276081},
journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 2:5/6,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1977},
month = {Sat Jan 01 00:00:00 EST 1977}
}