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Title: Effects of macrocyclic trichothecene mycotoxins on the murine immune system

Abstract

The macrocyclic trichothecenes are a unique group of toxins which have some antileukemic properties. In the first study, verrucarin A and roridin A were examined. Both mycotoxins were administered intraperitoneally at an equitoxic dose of 0.35 mg/kg to CD-1 mice. Lymphocyte proliferation was studied after animals were dosed with verrucarin A. After day 2, no differences in {sup 3}H-thymidine incorporation were observed using concanavalin A (Con A), phytohemagglutinin (PHA), pokeweed mitogen (PWM), or lipopolysaccharide (LPS). On day 4, DNA synthesis induced by Con A, PHA, and PWM increased significantly. On day 7, PHA stimulation increased above controls while Con A, PWM, and LPS responses were not significantly different. In contrast, roridin A decreased PHA stimulation only on day 7. In the second study the mycotoxins roritoxin B, myrotoxin B, roridin A, verrucarin A, 16-hydroxyverrucarin A, verrucarin J, baccharinoid B12, roridin D, roridin E, baccharinoid B4, and baccharinoid B5 were investigated. In the third study lymphocytes were cultured with each of the mycotoxins for 48 hr to assess their lethality.

Authors:
Publication Date:
Research Org.:
Utah State Univ., Logan, UT (USA)
OSTI Identifier:
5265281
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: Thesis (Ph. D.)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; LYMPHOCYTES; CELL PROLIFERATION; RETICULOENDOTHELIAL SYSTEM; SENSITIVITY; TOXINS; BIOLOGICAL EFFECTS; CONCANAVALIN; INTRAPERITONEAL INJECTION; LIPOPOLYSACCHARIDES; MICE; MITOGENS; PHYTOHEMAGGLUTININ; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AGGLUTININS; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; ANTIBODIES; ANTIGENS; AZINES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARBOHYDRATES; CONNECTIVE TISSUE CELLS; HEMAGGLUTININS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; INJECTION; INTAKE; ISOTOPE APPLICATIONS; LEUKOCYTES; LIPIDS; MAMMALS; MATERIALS; MUCOPROTEINS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; POLYSACCHARIDES; PROTEINS; PYRIMIDINES; RIBOSIDES; RODENTS; SACCHARIDES; SOMATIC CELLS; TISSUES; TOXIC MATERIALS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Hughes, B.J. Effects of macrocyclic trichothecene mycotoxins on the murine immune system. United States: N. p., 1988. Web.
Hughes, B.J. Effects of macrocyclic trichothecene mycotoxins on the murine immune system. United States.
Hughes, B.J. Fri . "Effects of macrocyclic trichothecene mycotoxins on the murine immune system". United States.
@article{osti_5265281,
title = {Effects of macrocyclic trichothecene mycotoxins on the murine immune system},
author = {Hughes, B.J.},
abstractNote = {The macrocyclic trichothecenes are a unique group of toxins which have some antileukemic properties. In the first study, verrucarin A and roridin A were examined. Both mycotoxins were administered intraperitoneally at an equitoxic dose of 0.35 mg/kg to CD-1 mice. Lymphocyte proliferation was studied after animals were dosed with verrucarin A. After day 2, no differences in {sup 3}H-thymidine incorporation were observed using concanavalin A (Con A), phytohemagglutinin (PHA), pokeweed mitogen (PWM), or lipopolysaccharide (LPS). On day 4, DNA synthesis induced by Con A, PHA, and PWM increased significantly. On day 7, PHA stimulation increased above controls while Con A, PWM, and LPS responses were not significantly different. In contrast, roridin A decreased PHA stimulation only on day 7. In the second study the mycotoxins roritoxin B, myrotoxin B, roridin A, verrucarin A, 16-hydroxyverrucarin A, verrucarin J, baccharinoid B12, roridin D, roridin E, baccharinoid B4, and baccharinoid B5 were investigated. In the third study lymphocytes were cultured with each of the mycotoxins for 48 hr to assess their lethality.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {1}
}

Thesis/Dissertation:
Other availability
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