The effect of three levels of copper on the mechanical properties of bone

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5264746

Smith, R T ^[1]

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1. Univ. of Southern Mississippi, Hattiesburg (United States)

The purpose of this study was to determine the effect of three levels of dietary copper on the mechanical properties of bone. Weaning male Sprague-Dawley rats were randomized to treatment groups which consumed a modified AIN-76 diet of either 6 ppm (Cu +), 0.6 ppm (Cu{minus}) or 300 ppm (Hi Cu) for six weeks. Bone strength and flexibility were determined on an Instron Universal Testing Machine for the right femur. Femur ash weight was also determined. Data were analyzed by ANCOVA with body weight as the covariate. There were no significant differences in strength, flexibility, or ash weight between any of the groups. These data would suggest that differences in bone strength do not occur by six weeks on Cu deficient diets and the Hi Cu was not effective in improving mechanical properties of bone.

• OSTI ID: 5264746
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COPPER
BIOLOGICAL EFFECTS
SKELETON
MECHANICAL PROPERTIES
METABOLISM
NUTRITIONAL DEFICIENCY
RATS
ANIMALS
BODY
ELEMENTS
MAMMALS
METALS
ORGANS
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology