Hepatic cytochrome P450 1A as a biomarker for hydrocarbon and oxidant pollutants in fish: Relevance of identification of specific mechanism(s) of induction and potential effects on homeostasis
Conference
·
OSTI ID:524689
- Univ. of Western Ontario, London, Ontario (Canada). Dept. of Pharmacology and Toxicology
- Woods Hole Oceanographic Inst., MA (United States). Dept. of Biology
The induction of hepatic and extrahepatic P450 1A isozymes in fish and mammals is used as a biomarker for certain classes of toxic environmental pollutants, including polycyclic aromatic hydrocarbons (PAHs), planar polychlorinated (PCBs) and polybrominated (PBBs) biphenyl congeners, polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). However, recent data from the laboratory have shown that rat pulmonary P450 1A1 can also be induced by arsenite or liver transplantation (via a stress mechanism), raising the possibility that regulation of this biomarker can occur by mechanisms other than Ah receptor-mediated increases of CYP1A gene transcription.
- OSTI ID:
- 524689
- Report Number(s):
- CONF-9404330-; TRN: IM9740%%163
- Resource Relation:
- Conference: 4. Symposium on environmental toxicology and risk assessment: transboundary issues in pollution, Montreal (Canada), 11-13 Apr 1994; Other Information: PBD: 1996; Related Information: Is Part Of Environmental toxicology and risk assessment: Fourth volume; La Point, T.W.; Price, F.T.; Little, E.E. [eds.]; PB: 287 p.; ASTM special technical publication, 1262
- Country of Publication:
- United States
- Language:
- English
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