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Title: Thyroid function following neck irraidation for malignant lymphoma

Abstract

Thyroid function tests for T/sub 3/ resin (T/sub 3/-r), serum thyroxine (T/sub 4/), and serum thyroid stimulating hormone (TSH) were measured in 70 consecutive patients who had previously undergone lymphangiography and neck irradiation for malignant lymphoma. All were in remission and clinically euthyroid. The abnormalities found were: 23 (33%) patients hypothyroid by TSH, 14 (20%) with subnormal T/sub 4/, and 21 (30%) with subnormal T/sub 3/-r values. None of the patients were biochemically hyperthyroid. The prevalence and magnitude of abnormalities were highest during the third year after irradiation, thereafter decreasing with time.

Authors:
; ;
Publication Date:
Research Org.:
Univ. Hospital, Ann Arbor, MI
OSTI Identifier:
5246591
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiology; (United States); Journal Volume: 134:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; HYPOTHYROIDISM; RADIOINDUCTION; RADIOTHERAPY; SIDE EFFECTS; THYROID; DELAYED RADIATION EFFECTS; CESIUM 137; COBALT 60; GAMMA RADIATION; LYMPHOMAS; NECK; PARTIAL BODY IRRADIATION; PATIENTS; THYROXINE; TIME DEPENDENCE; TRIIODOTHYRONINE; TSH; ALKALI METAL ISOTOPES; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; BODY AREAS; CARBOXYLIC ACIDS; CESIUM ISOTOPES; COBALT ISOTOPES; DISEASES; ELECTROMAGNETIC RADIATION; ENDOCRINE DISEASES; ENDOCRINE GLANDS; EXTERNAL IRRADIATION; GLANDS; HORMONES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; PEPTIDE HORMONES; PITUITARY HORMONES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RADIOLOGY; THERAPY; THYROID HORMONES; YEARS LIVING RADIOISOTOPES; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Kim, Y.H., Fayos, J.V., and Sisson, J.C.. Thyroid function following neck irraidation for malignant lymphoma. United States: N. p., 1980. Web.
Kim, Y.H., Fayos, J.V., & Sisson, J.C.. Thyroid function following neck irraidation for malignant lymphoma. United States.
Kim, Y.H., Fayos, J.V., and Sisson, J.C.. 1980. "Thyroid function following neck irraidation for malignant lymphoma". United States. doi:.
@article{osti_5246591,
title = {Thyroid function following neck irraidation for malignant lymphoma},
author = {Kim, Y.H. and Fayos, J.V. and Sisson, J.C.},
abstractNote = {Thyroid function tests for T/sub 3/ resin (T/sub 3/-r), serum thyroxine (T/sub 4/), and serum thyroid stimulating hormone (TSH) were measured in 70 consecutive patients who had previously undergone lymphangiography and neck irradiation for malignant lymphoma. All were in remission and clinically euthyroid. The abnormalities found were: 23 (33%) patients hypothyroid by TSH, 14 (20%) with subnormal T/sub 4/, and 21 (30%) with subnormal T/sub 3/-r values. None of the patients were biochemically hyperthyroid. The prevalence and magnitude of abnormalities were highest during the third year after irradiation, thereafter decreasing with time.},
doi = {},
journal = {Radiology; (United States)},
number = ,
volume = 134:1,
place = {United States},
year = 1980,
month = 1
}
  • The effects on the thyroid of radiation therapy to the neck and/or chemotherapy were investigated in 54 Hodgkin's and 72 non-Hodgkin's lymphoma patients. These patients had received radiation therapy with doses ranging from 2000 to 4000 rad (median 3600 rad) to the cervical or mantle fields and/or multiple-agent chemotherapy following usual staging procedures. Palpable abnormalities of the thyroid were found in 15 patients. The patients with irradiation to the neck had a higher incidence of hypothyroidism than those patients treated with chemotherapy alone (31/74 vs. 8/52, P less than 0.001 for TSH and 10/74 vs. 1/52, P less than 0.025more » for T4). A higher frequency of elevated serum TSH levels and antithyroid antibodies were also observed in patients receiving radiation therapy alone to the neck than in those receiving both radiation therapy and chemotherapy (19/33 vs. 12/41, P less than 0.025 for TSH and 16/33 vs. 7/41, p less than 0.01 for antibodies), suggesting that chemotherapy agents may reduce the thyroid dysfunction induced by irradiation. There was no difference in prevalence of elevated TSH levels following irradiation to the neck between patients in whom lymphangiogram was or was not performed (21/51 vs. 10/23).« less
  • While /sup 67/Ga uptake has been reported to be highly variable and nonspecific in the diagnosis of malignant tumors of the thyroid, it has also been observed to depend on the histological nature of the lesion. For this reason, the behavior of /sup 67/Ga in various types of thyroid cancer was investigated in a prospective study of 86 patients with thyroid masses compatible with anaplastic carcinoma or malignant lymphoma. The study demonstrated a distinct difference in uptake between well-differentiated adenocarcinoma of the thyroid and the more undifferentiated anaplastic carcinoma and malignant lymphoma.
  • Technetium-99m-labelled pertechnetate in combination with a gamma camera produces very high resolution thyroid images. In patients with a history of neck irradiation, nonpalpable cold nodules can now be detected. Either a palpable nodule or nonpalpable cold area on scintiphoto is sufficient indication to at least consider surgical operation. (ERB)