Excretion of stable isotopes in man: A valuable source of information on trace metal kinetics

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5240116

Fennessey, P V; Miller, L V; Westcott, J E; Kindstrand, L; Hambidge, K M ^[1]

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1. Univ. of Colorado, Denver (United States)

The analysis of individual fecal samples collected for at least ten days following an oral dose of {sup 70}Zn provides data on transit time, absorption and the excretion of isotope that has been absorbed and then secreted back into the lumen of the intestine. The analysis of data from more than 80 human studies where enriched Zn stable isotopes were given orally has provided a valuable data base on Zn kinetics. A plot of enrichment in the fecal samples as a function of time reveals the average time of maximum appearance as well as the time limit needed for elimination of unabsorbed isotope. A plot of cumulative enrichment as a function of time reveals information on both absorption and secretion rate of absorbed isotope. This data base provides investigators with new information that they can use to optimize their data collection schemes and serves as a model for the study of other trace metals.

• OSTI ID: 5240116
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ZINC
METABOLISM
EXCRETION
FECES
INTESTINAL ABSORPTION
MAN
TRACER TECHNIQUES
ZINC 70
ABSORPTION
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CLEARANCE
ELEMENTS
EVEN-EVEN NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
METALS
NUCLEI
PRIMATES
STABLE ISOTOPES
UPTAKE
VERTEBRATES
WASTES
ZINC ISOTOPES
560300* - Chemicals Metabolism & Toxicology