Efficient stereospecific synthesis of no-carrier-added 2-(18F)-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution

Journal Article · Sat Feb 01 00:00:00 EST 1986 · J. Nucl. Med.; (United States)

OSTI ID:5239994

Hamacher, K; Coenen, H H; Stoecklin, G

An aminopolyether mediated synthesis of fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) has been developed. The nucleophilic fluorination with accelerator-produced (18F)fluoride works at the no-carrier-added level and gives epimerically pure 2-18FDG with an uncorrected radiochemical yield of a maximum 50% in a synthesis time of approximately 50 min from EOB.

• Research Organization: Institut fuer Chemie 1 (Nuklearchemie), Juelich, Germany, F.R.
• OSTI ID: 5239994
• Journal Information: J. Nucl. Med.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
GLUCOSE
FLUORINATION
CHEMICAL PREPARATION
ETHERS
FLUORINE 18
LABELLED COMPOUNDS
LABELLING
POLYMERS
RADIOCHEMISTRY
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CHEMICAL REACTIONS
CHEMISTRY
FLUORINE ISOTOPES
HALOGENATION
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
RADIOISOTOPES
SACCHARIDES
SYNTHESIS
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials