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Title: (New imaging systems in nuclear medicine)

Abstract

We continue to use and maintain PCR-I, the single-slice high- resolution high-sensitivity positron emission tomograph, while development proceeds on PCR-II, a three-dimensional PET system. A two-dimensional BGO scintillation detector has been designed and we are nearing completion of the detector, including the light guide, crystals and phototube assembly, and the gantry electronics. We are currently exploring techniques for a very high resolution (sub-mm) PET imaging system. We are using the current PCR-I system to assess changes in presynaptic dopamine receptors and glucose utilization in current biological models of Huntington's disease. Our preliminary studies support the use of the primate (Cynomolgus monkey) model of Huntington's disease to monitor in vivo functional changes. We are planning to extend this study to examine the MPTP model of Parkinson disease, and to assess the therapeutic value of D{sub 1} dopamine receptor agonists for treatment of MPTP-induced neurological defects. 13 refs., 5 figs. (MHB)

Publication Date:
Research Org.:
Massachusetts General Hospital, Boston, MA (United States). Physics Research Lab.
Sponsoring Org.:
USDOE; USDOE, Washington, DC (United States)
OSTI Identifier:
5228478
Report Number(s):
DOE/ER/60519-T3
ON: DE92000786
DOE Contract Number:
FG02-87ER60519
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; BGO DETECTORS; DESIGN; BRAIN; POSITRON COMPUTED TOMOGRAPHY; NERVOUS SYSTEM DISEASES; BIOLOGICAL MODELS; NUCLEAR MEDICINE; RADIATION SOURCES; ANALOG SYSTEMS; BLOOD FLOW; CARBON 11; COMPUTER CODES; COMPUTER NETWORKS; DATA TRANSMISSION; DOPAMINE; FLUORINE 18; FLUORODEOXYGLUCOSE; LIGANDS; MONTE CARLO METHOD; POSITRON CAMERAS; PROGRESS REPORT; RECEPTORS; SCATTERING; SHIELDING; THREE-DIMENSIONAL CALCULATIONS; TISSUE DISTRIBUTION; TWO-DIMENSIONAL CALCULATIONS; AMINES; ANTIMETABOLITES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CAMERAS; CARBON ISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COMMUNICATIONS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; DOCUMENT TYPES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; GAMMA CAMERAS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MEASURING INSTRUMENTS; MEDICINE; MEMBRANE PROTEINS; MINUTES LIVING RADIOISOTOPES; NANOSEC LIVING RADIOISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PROTEINS; RADIATION DETECTORS; RADIOISOTOPES; SCINTILLATION COUNTERS; SOLID SCINTILLATION DETECTORS; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 440101 - Radiation Instrumentation- General Detectors or Monitors & Radiometric Instruments

Citation Formats

Not Available. (New imaging systems in nuclear medicine). United States: N. p., 1991. Web.
Not Available. (New imaging systems in nuclear medicine). United States.
Not Available. 1991. "(New imaging systems in nuclear medicine)". United States. doi:.
@article{osti_5228478,
title = {(New imaging systems in nuclear medicine)},
author = {Not Available},
abstractNote = {We continue to use and maintain PCR-I, the single-slice high- resolution high-sensitivity positron emission tomograph, while development proceeds on PCR-II, a three-dimensional PET system. A two-dimensional BGO scintillation detector has been designed and we are nearing completion of the detector, including the light guide, crystals and phototube assembly, and the gantry electronics. We are currently exploring techniques for a very high resolution (sub-mm) PET imaging system. We are using the current PCR-I system to assess changes in presynaptic dopamine receptors and glucose utilization in current biological models of Huntington's disease. Our preliminary studies support the use of the primate (Cynomolgus monkey) model of Huntington's disease to monitor in vivo functional changes. We are planning to extend this study to examine the MPTP model of Parkinson disease, and to assess the therapeutic value of D{sub 1} dopamine receptor agonists for treatment of MPTP-induced neurological defects. 13 refs., 5 figs. (MHB)},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 1991,
month = 1
}

Technical Report:
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  • This progress report covers four areas: development of positron instrumentation, development of NUMEDICS computer system and software, application of cyclotron-produced isotopes (/sup 11/C, /sup 68/Ga, /sup 13/N, /sup 15/O, and /sup 82/Rb), and application of the NUMEDICS computer system in nuclear medicine. The development of transverse section positron imaging has had a significant impact and a positron camera was designed specifically for transverse section imaging of heart and lungs. The computer net (NUMEDICS II) is progressing rapidly in design and software development. Clinical studies have demonstrated the feasibility of measuring cerebral blood flow using a variety of positron emitting radiopharmaceuticalsmore » and oxygen utilization using /sup 15/O/sub 2/. Rubidium-82 also appears to be a promising agent for measurement of cerebral blood flow.« less
  • The past year has seen gratifying results in the performance of PCR-I, the single ring analog coded positron tomograph, and in the development of the design of PCR-II, a cylindrical positron tomograph using two-dimensional analog coding. Analog coding provides high resolution imaging together with high count-rate capability. A computer system capable of handling the enormous amount of data generated by PCR-II is being developed. It will also be used to simulate the performance of the final system during its development. 2 figs.
  • The aim of this program has been to improve the performance of positron emission tomography (PET) to achieve high resolution with high sensitivity. Towards this aim, the authors have carried out the following studies: (1) explored new techniques for detection of annihilation radiation including new detector materials and system geometries, specific areas that they have studied include--exploration of factors related to resolution and sensitivity of PET instrumentation including geometry, detection materials and coding, and the exploration of technique to improve the image quality by use of depth of interaction and increased sampling; (2) complete much of the final testing ofmore » PCR-II, an analog-coded cylindrical positron tomograph, developed and constructed during the current funding period; (3) developed the design of a positron microtomograph with mm resolution for quantitative studies in small animals, a single slice version of this device has been designed and studied by use of computer simulation; (4) continued and expanded the program of biological studies in animal models. Current studies have included imaging of animal models of Parkinson`s and Huntington`s disease and cancer. These studies have included new radiopharmaceuticals and techniques involving molecular biology.« less
  • Developments of improved imaging systems in nuclear medicine are reported with emphasis on development of positron emission tomographs that combine high resolution, with high sensitivity and high count rate capability. A second generation cylindrical analog positron camera design has provided excellent light collection with limited light spread, characteristics needed for high spatial and temporal resolution. Other aspects of the camera development include the design of associated electronics, and provision for data storage and processing. Utilizing the above camera basic studies have been performed to evaluate blood flow in the cat brain stem during auditory stimulation, ventilation in the dog usingmore » /sup 13/N and blood flow in the canine heart. 2 refs., 2 figs.« less