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Title: Effect of smokeless tobacco and tobacco-related chemical carcinogens on survival of ultraviolet light-inactivated herpes simplex virus

Abstract

Low doses of ultraviolet (UV) light, x-rays, photodynamic treatment, or aflatoxins increase the survival of UV-irradiated virus in cells. This effect is postulated to occur by enhancement of the error-prone cellular repair function, which could also be associated with oncogenic cell transformation. The present study was designed to investigate whether treatment of green monkey kidney cells with water extract of snuff (snuff extract), benzo(a)pyrene, nicotine, or tobacco-specific N'-nitrosamines would result in enhanced survival of UV-irradiated herpes simplex virus (HSV). Exposure of the cells with snuff extract, benzo(a)pyrene, N'-nitrosonornicotine, or 4-(N-methyl-N'-nitrosamino)-1-(3-pyridyl)-1-butanone resulted in an enhancement of survival of UV-irradiated HSV type 1 compared with the control whereas exposure of the cells with nicotine did not. These data indicate that the water-extractable component of snuff and tobacco-related chemical carcinogens increase the cellular repair mechanism and provides for increased survival of UV-irradiated HSV.

Authors:
; ; ;  [1]
  1. (Section of Oral and Maxillofacial Surgery, UCLA School of Dentistry (USA))
Publication Date:
OSTI Identifier:
5197596
Resource Type:
Journal Article
Resource Relation:
Journal Name: Oral Surgery, Oral Medicine, Oral Pathology; (United States); Journal Volume: 71:4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BENZOPYRENE; RADIOSENSITIVITY EFFECTS; NICOTINE; NITROSAMINES; VIRUSES; INACTIVATION; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; CARCINOGENS; HERPES SIMPLEX; MONKEYS; SURVIVAL TIME; TOBACCO; ULTRAVIOLET RADIATION; X RADIATION; ALKALOIDS; AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZINES; AZOLES; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; CONDENSED AROMATICS; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; INFECTIOUS DISEASES; IONIZING RADIATIONS; MAMMALS; MICROORGANISMS; NITROSO COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PARASITES; PARASYMPATHOLYTICS; PARASYMPATHOMIMETICS; PRIMATES; PYRIDINES; PYRROLES; PYRROLIDINES; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; SKIN DISEASES; VERTEBRATES; VIRAL DISEASES; 560130* - Radiation Effects on Microorganisms; 560300 - Chemicals Metabolism & Toxicology

Citation Formats

Dokko, H., Min, P.S., Cherrick, H.M., and Park, N.H.. Effect of smokeless tobacco and tobacco-related chemical carcinogens on survival of ultraviolet light-inactivated herpes simplex virus. United States: N. p., 1991. Web. doi:10.1016/0030-4220(91)90431-B.
Dokko, H., Min, P.S., Cherrick, H.M., & Park, N.H.. Effect of smokeless tobacco and tobacco-related chemical carcinogens on survival of ultraviolet light-inactivated herpes simplex virus. United States. doi:10.1016/0030-4220(91)90431-B.
Dokko, H., Min, P.S., Cherrick, H.M., and Park, N.H.. Mon . "Effect of smokeless tobacco and tobacco-related chemical carcinogens on survival of ultraviolet light-inactivated herpes simplex virus". United States. doi:10.1016/0030-4220(91)90431-B.
@article{osti_5197596,
title = {Effect of smokeless tobacco and tobacco-related chemical carcinogens on survival of ultraviolet light-inactivated herpes simplex virus},
author = {Dokko, H. and Min, P.S. and Cherrick, H.M. and Park, N.H.},
abstractNote = {Low doses of ultraviolet (UV) light, x-rays, photodynamic treatment, or aflatoxins increase the survival of UV-irradiated virus in cells. This effect is postulated to occur by enhancement of the error-prone cellular repair function, which could also be associated with oncogenic cell transformation. The present study was designed to investigate whether treatment of green monkey kidney cells with water extract of snuff (snuff extract), benzo(a)pyrene, nicotine, or tobacco-specific N'-nitrosamines would result in enhanced survival of UV-irradiated herpes simplex virus (HSV). Exposure of the cells with snuff extract, benzo(a)pyrene, N'-nitrosonornicotine, or 4-(N-methyl-N'-nitrosamino)-1-(3-pyridyl)-1-butanone resulted in an enhancement of survival of UV-irradiated HSV type 1 compared with the control whereas exposure of the cells with nicotine did not. These data indicate that the water-extractable component of snuff and tobacco-related chemical carcinogens increase the cellular repair mechanism and provides for increased survival of UV-irradiated HSV.},
doi = {10.1016/0030-4220(91)90431-B},
journal = {Oral Surgery, Oral Medicine, Oral Pathology; (United States)},
number = ,
volume = 71:4,
place = {United States},
year = {Mon Apr 01 00:00:00 EST 1991},
month = {Mon Apr 01 00:00:00 EST 1991}
}