Effect of smokeless tobacco and tobacco-related chemical carcinogens on survival of ultraviolet light-inactivated herpes simplex virus

Journal Article · Mon Apr 01 00:00:00 EST 1991 · Oral Surgery, Oral Medicine, Oral Pathology; (United States)

DOI:https://doi.org/10.1016/0030-4220(91)90431-B· OSTI ID:5197596

Dokko, H; Min, P S; Cherrick, H M; Park, N H ^[1]

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1. Section of Oral and Maxillofacial Surgery, UCLA School of Dentistry (USA)

Low doses of ultraviolet (UV) light, x-rays, photodynamic treatment, or aflatoxins increase the survival of UV-irradiated virus in cells. This effect is postulated to occur by enhancement of the error-prone cellular repair function, which could also be associated with oncogenic cell transformation. The present study was designed to investigate whether treatment of green monkey kidney cells with water extract of snuff (snuff extract), benzo(a)pyrene, nicotine, or tobacco-specific N'-nitrosamines would result in enhanced survival of UV-irradiated herpes simplex virus (HSV). Exposure of the cells with snuff extract, benzo(a)pyrene, N'-nitrosonornicotine, or 4-(N-methyl-N'-nitrosamino)-1-(3-pyridyl)-1-butanone resulted in an enhancement of survival of UV-irradiated HSV type 1 compared with the control whereas exposure of the cells with nicotine did not. These data indicate that the water-extractable component of snuff and tobacco-related chemical carcinogens increase the cellular repair mechanism and provides for increased survival of UV-irradiated HSV.

• OSTI ID: 5197596
• Journal Information: Oral Surgery, Oral Medicine, Oral Pathology; (United States), Vol. 71:4; ISSN 0030-4220
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOPYRENE
RADIOSENSITIVITY EFFECTS
NICOTINE
NITROSAMINES
VIRUSES
INACTIVATION
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL REPAIR
CARCINOGENS
HERPES SIMPLEX
MONKEYS
SURVIVAL TIME
TOBACCO
ULTRAVIOLET RADIATION
X RADIATION
ALKALOIDS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
CONDENSED AROMATICS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INFECTIOUS DISEASES
IONIZING RADIATIONS
MAMMALS
MICROORGANISMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
PRIMATES
PYRIDINES
PYRROLES
PYRROLIDINES
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SKIN DISEASES
VERTEBRATES
VIRAL DISEASES
560130* - Radiation Effects on Microorganisms
560300 - Chemicals Metabolism & Toxicology