Radiometric method for pyrazinamide susceptibility testing of Mycobacterium tuberculosis in egg-yolk-enriched BACTEC 12A medium

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Antimicrob. Agents Chemother.; (United States)

DOI:https://doi.org/10.1128/AAC.32.1.125· OSTI ID:5194320

Woodley, C L; Smithwick, R W

A radiometric method for testing the susceptibility of Mycobacterium tuberculosis to pyrazinamide in egg-yolk-enriched 12A medium (pH 5.5) is described. We obtained 100% agreement between the 7H10 agar method with 25 microgram of pyrazinamide per ml and the modified radiometric method with a drug concentration of 50 microgram/ml in tests of 90 clinical isolates.

• Research Organization: Centers for Disease Control, Atlanta, GA (USA)
• OSTI ID: 5194320
• Journal Information: Antimicrob. Agents Chemother.; (United States), Vol. 32:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MYCOBACTERIUM TUBERCULOSIS
SENSITIVITY
PYRAZINES
BIOLOGICAL EFFECTS
AMIDES
CULTURE MEDIA
RADIOMETRIC ANALYSIS
AZINES
BACTERIA
CHEMICAL ANALYSIS
HETEROCYCLIC COMPOUNDS
MICROORGANISMS
MYCOBACTERIUM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
QUANTITATIVE CHEMICAL ANALYSIS
560300* - Chemicals Metabolism & Toxicology