Localization of the human gene for macrophage migration inhibitory factor (MIF) to chromosome 22q11.2

Journal Article · Wed Jan 15 00:00:00 EST 1997 · Genomics

DOI:https://doi.org/10.1006/geno.1996.4505· OSTI ID:518314

Budarf, M ^[1]; McDonald, T; Sellinger, B ^[2]

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1. Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States)
2. Children`s Hospital of Philadelphia, PA (United States); and others

Macrophage migration inhibitory factor (MIF) is a lymphokine activity associated with early phases of the inflammatory response. The name MIF was later given to a small protein identified by expression cloning from activated T-cells. This protein is widely expressed in tissues regardless of immune status and has been identified with several different activities. Most recently it has become clear that MIF belongs to a superfamily of small isomerases. Whatever its physiological role(s), MIF gene expression is induced by different growth factors in a delayed early responses and is associated with processes of proliferation and differentiation. 16 refs., 1 fig.

• OSTI ID: 518314
• Journal Information: Genomics, Vol. 39, Issue 2; Other Information: PBD: 15 Jan 1997
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
GENETIC MAPPING
DNA-CLONING
GENE REGULATION
TISSUE DISTRIBUTION
HUMAN CHROMOSOME 22
CHROMOSOMAL ABERRATIONS
MACROPHAGES
MIGRATION
CELL DIFFERENTIATION
CELL PROLIFERATION
CHROMOSOMES
LYMPHOKINES
GROWTH FACTORS
COSMIDS
DNA HYBRIDIZATION
FLUORESCENCE
IN-SITU HYBRIDIZATION
HEREDITARY DISEASES
MICE
POLYMERASE CHAIN REACTION