Effect of moderate alcohol consumption on plasma opiate levels in premenopausal women

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5174465

Bhathena, S J; Kim, Y C; Law, J S; Berlin, E; T, Judd J; Reichman, M E; Taylor, P R; Schatzkin, A ^[1]

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1. Dept. of Agriculture, Beltsville, MD (United States) NCI, Bethesda, MD (United States)

Opiate changes have been reported in response to excessive alcohol consumption. Different phases of the menstrual cycle also affect the opiate tone. The authors studied the effect of moderate alcohol consumption and the menstrual cycle per se on plasma opiates. Forty premenopausal women were given alcohol or a soft drink of equal caloric value for 3 menstrual cycles in a cross over study. The subjects were fed a controlled diet containing 35% of energy from fat. Blood was collected in the third menstrual cycle of each period during follicular (F), ovulatory (O) and luteal (L) phases. {beta}-endorphin, met-enkephalin and lwu-enkephalin (LE) were measured by radioimmunoassay. None of the opiates showed significant change after alcohol consumption though LE was consistently higher after alcohol consumption during all three phases of the menstrual cycle. There was a significant decrease in BEN during L phase compared to F phase while both enkephalins were higher during L phase than during F phase. Opiate levels during O phase were intermediate between F and L. Thus, in contrast to previously observed opiate changes following excessive alcohol consumption, they did not observe changes with moderate consumption.

• OSTI ID: 5174465
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ENDORPHINS
BIOSYNTHESIS
ETHANOL
BIOLOGICAL EFFECTS
MENSTRUAL CYCLE
METABOLISM
RADIOIMMUNOASSAY
WOMEN
ALCOHOLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOASSAY
DIAGNOSTIC TECHNIQUES
DRUGS
FEMALES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
MAN
NEUROREGULATORS
ORGANIC COMPOUNDS
PRIMATES
RADIOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
SYNTHESIS
TRACER TECHNIQUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology