Phytic acid plus calcium, but not phytic acid alone, decreases fluoride bioavailability in the rat

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5173110

Cerklewski, F L ^[1]

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1. Oregon State Univ., Corvallis (United States)

Results of in vitro studies have suggested that fluoride becomes insoluble when some soy-based infant formulas are diluted with fluoridated water because of the presence of phytate, added calcium or a combination of these factors. The present study was designed to test this hypothesis in vivo. Male albino rats were fed a purified diet containing phytic acid, calcium and fluoride for 4 weeks in a factorial design of treatments. Phytic acid was added to the diet by chemically reacting a phytic acid concentrate with casein prior to diet preparation to mimic a soy-protein. Food intake, weight gain and femur P were unaffected by dietary treatments. Both phytic acid and supplemental calcium alone had little or no effect upon fluoride uptake into either bone or teeth. The combination of phytic acid plus supplemental calcium, however, significantly increased % of fluoride intake found in the feces which was reflected in a significant decrease in fluoride concentration of femur, 2nd molar teeth and vertebrate bone. These results provide evidence that insoluble complex formation produced by a calcium and phytate interaction can explain reduced fluoride solubility in some soy-based infant formulas as well as decreased fluoride absorbability in vivo.

• OSTI ID: 5173110
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CALCIUM
BIOLOGICAL EFFECTS
FLUORIDES
BIOLOGICAL AVAILABILITY
PHYTIC ACID
METABOLISM
RATS
SOLUBILITY
ALKALINE EARTH METALS
ANIMALS
ELEMENTS
ESTERS
FLUORINE COMPOUNDS
HALIDES
HALOGEN COMPOUNDS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHORIC ACID ESTERS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology