Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy
A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.
- Research Organization:
- Associated Universities Inc
- Sponsoring Organization:
- USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- Associated Universities, Inc., Washington, DC (United States)
- Patent Number(s):
- US 5,653,957/A/
- Application Number:
- PAN: 8-740,693; CNN: Grant IR01CA38107-01A2; TRN: 97:014586
- OSTI ID:
- 516929
- Resource Relation:
- Other Information: PBD: 5 Aug 1997
- Country of Publication:
- United States
- Language:
- English
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Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy
Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy