Plasminogen activator as a diagnostic marker for preneoplastic cells in human gynecologic specimens

Journal Article · Thu Mar 01 00:00:00 EST 1979 · Acta Cytol.; (United States)

OSTI ID:5163346

Jensen, R H; Bigbee, W L; Zimmerman, A L; King, E B

A modified fibrin-agar overlay assay was used to measure the fibrinolytic activity in human cervical epithelial cells. The fibrinolytic activity results from a cell-associated serine protease that acts as a plasminogen activator. An enzymatic and morphologic comparison of individual normal and abnormal cells reveals that about 50% of the dysplastic and carcinoma in situ cells contain high levels of the activator. Forty percent of morphologically normal metaplastic cells also exhibit high activities of plasminogen. Forty percent of morphologically normal metaplastic cells also exhibit high activities of plasminogen activator. Most normal intermediate and superficial epithelial cells and all erythrocytes and leukocytes are inactive. The frequency of plasminogen activator-containing cells was somewhat higher in cytomorphologically abnormal samples than in normal samples.

• Research Organization: Univ. of California, Livermore
• OSTI ID: 5163346
• Journal Information: Acta Cytol.; (United States), Vol. 23:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
NEOPLASMS
DIAGNOSIS
TUMOR CELLS
BIOCHEMICAL REACTION KINETICS
BIOASSAY
EPITHELIUM
FIBRINOLYSIS
GYNECOLOGY
MORPHOLOGY
ANIMAL CELLS
BODY
CHEMICAL REACTIONS
DECOMPOSITION
DISEASES
KINETICS
MEDICINE
PROTEOLYSIS
REACTION KINETICS
TISSUES
550600* - Medicine
551000 - Physiological Systems