Solvent-refined-coal (SRC) process: health programs. Research and development report No. 53. Interim report No. 76. Volume III. Pilot plant development work. Part 4. Industrial hygiene, clinical and toxicological programs. Final report of Subcontract No. 13, August 1, 1980-March 31, 1982
This final report summarizes the mutagenic studies conducted on SRC-II materials as part of the toxicological program under the Solvent Refined Coal (SRC) Process Contract for the period August 1, 1980 through March 31, 1982. Three Tasks were conducted on each of the following materials: coal slurry, middle distillate and stripper tower bottoms. One Task, a Saccharomyces/Mammalian-microsome mutagenicity study, involved the use of a eukaryotic microorganism capable of detecting mitotic crossing-over. Another Task, a dermal cytogenetics study in rats, concerned the analysis of cells from the bone marrow of rats dermally exposed to the test materials for the presence of chemically induced genetic alterations in chromosome number and structure. The third Task, the unscheduled DNA synthesis in primary rat liver cell cultures, involved the evaluation of the capability of the test materials to induce damage to the DNA. All studies were performed according to approved detailed protocols, FDA Good Laboratory practice Regulations, and quality assurance audits. The only positive mutagenic response to coal slurry and stripper tower bottoms was observed in the unscheduled DNA synthesis experiments. The only positive response to middle distillate was observed in the female animals in the dermal cytogenetics studies. However, the significance of this finding is uncertain in light of other stresses imposed on the animals.
- Research Organization:
- Pittsburg and Midway Coal Mining Co., Englewood, CO (USA); SRI International, Menlo Park, CA (USA)
- DOE Contract Number:
- AC05-76ET10104
- OSTI ID:
- 5151038
- Report Number(s):
- DOE/ET/10104-57; ON: DE82013839
- Resource Relation:
- Other Information: Portions of document are illegible
- Country of Publication:
- United States
- Language:
- English
Similar Records
Solvent-refined-coal (SRC) process: health programs. Research and development report No. 53, Interim report No. 39. Volume III. Pilot plant development work. Part 4: Industrial hygiene, clinical and toxicological programs. Final report of subcontract No. 10, June 1, 1976-June 9, 1978
Solvent refined coal (SRC) process: health programs research and development report No. 53. Volume III. Pilot plant development work. Part 4. Industrial hygiene, clinical, and toxicological programs. Interim report No. 32, July 1, 1978 through December 31, 1979
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COAL LIQUIDS
BIOLOGICAL EFFECTS
MUTAGEN SCREENING
TOXICITY
DISTILLATES
GAS CHROMATOGRAPHY
FUEL SLURRIES
RESIDUES
SRC-II PROCESS
AUTORADIOGRAPHY
BONE MARROW CELLS
CELL CULTURES
COAL LIQUEFACTION
CROSSING-OVER
DAMAGE
DNA
EXPERIMENTAL DATA
GENETIC EFFECTS
INDUSTRIAL MEDICINE
MICROORGANISMS
MICROSOMES
MUTAGENS
RATS
SKIN
YEASTS
ANIMAL CELLS
ANIMALS
BODY
CELL CONSTITUENTS
CHROMATOGRAPHY
CONNECTIVE TISSUE CELLS
DATA
DISPERSIONS
FLUIDS
FUELS
FUNGI
INFORMATION
LIQUEFACTION
LIQUIDS
MAMMALS
MEDICINE
MIXTURES
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PLANTS
RODENTS
SCREENING
SEPARATION PROCESSES
SLURRIES
SOMATIC CELLS
SUSPENSIONS
THERMOCHEMICAL PROCESSES
VERTEBRATES
010405* - Coal
Lignite
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