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Title: Prognostic significance of normal quantitative planar thallium-201 stress scintigraphy in patients with chest pain

Abstract

The prognostic significance of normal quantitative planar thallium-201 stress scintigraphy was evaluated in patients with a chest pain syndrome. The prevalence of cardiac events during follow-up was related to the pretest (that is, before stress scintigraphy) likelihood of coronary artery disease determined on the basis of symptoms, age, sex and stress electrocardiography. In a consecutive series of 344 patients who had adequate thallium-201 stress scintigrams, 95 had unequivocally normal studies by quantitative analysis. The pretest likelihood of coronary artery disease in the 95 patients had a bimodal distribution. During a mean follow-up period of 22 +/- 3 months, no patient died. Three patients (3%) had a cardiac event: two of these patients (pretest likelihood of coronary artery disease 54 and 94%) had a nonfatal myocardial infarction 8 and 22 months, respectively, after stress scintigraphy, and one patient (pretest likelihood 98%) underwent percutaneous transluminal coronary angioplasty 16 months after stress scintigraphy for persisting anginal complaints. Three patients were lost to follow-up; all three had a low pretest likelihood of coronary artery disease. It is concluded that patients with chest pain and normal findings on quantitative thallium-201 scintigraphy have an excellent prognosis. Cardiac events are rare (infarction rate 1% per year) andmore » occur in patients with a moderate to high pretest likelihood of coronary artery disease.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of Vermont College of Medicine, Burlington
OSTI Identifier:
5150565
Resource Type:
Journal Article
Journal Name:
J. Am. Coll. Cardiol.; (United States)
Additional Journal Information:
Journal Volume: 1
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEART; SCINTISCANNING; MYOCARDIAL INFARCTION; PAIN; PATIENTS; PROBABILITY; THALLIUM 201; TIME DEPENDENCE; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; SYMPTOMS; THALLIUM ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Wackers, F.J., Russo, D.J., Russo, D., and Clements, J.P. Prognostic significance of normal quantitative planar thallium-201 stress scintigraphy in patients with chest pain. United States: N. p., 1985. Web. doi:10.1016/S0735-1097(85)80247-3.
Wackers, F.J., Russo, D.J., Russo, D., & Clements, J.P. Prognostic significance of normal quantitative planar thallium-201 stress scintigraphy in patients with chest pain. United States. doi:10.1016/S0735-1097(85)80247-3.
Wackers, F.J., Russo, D.J., Russo, D., and Clements, J.P. Mon . "Prognostic significance of normal quantitative planar thallium-201 stress scintigraphy in patients with chest pain". United States. doi:10.1016/S0735-1097(85)80247-3.
@article{osti_5150565,
title = {Prognostic significance of normal quantitative planar thallium-201 stress scintigraphy in patients with chest pain},
author = {Wackers, F.J. and Russo, D.J. and Russo, D. and Clements, J.P.},
abstractNote = {The prognostic significance of normal quantitative planar thallium-201 stress scintigraphy was evaluated in patients with a chest pain syndrome. The prevalence of cardiac events during follow-up was related to the pretest (that is, before stress scintigraphy) likelihood of coronary artery disease determined on the basis of symptoms, age, sex and stress electrocardiography. In a consecutive series of 344 patients who had adequate thallium-201 stress scintigrams, 95 had unequivocally normal studies by quantitative analysis. The pretest likelihood of coronary artery disease in the 95 patients had a bimodal distribution. During a mean follow-up period of 22 +/- 3 months, no patient died. Three patients (3%) had a cardiac event: two of these patients (pretest likelihood of coronary artery disease 54 and 94%) had a nonfatal myocardial infarction 8 and 22 months, respectively, after stress scintigraphy, and one patient (pretest likelihood 98%) underwent percutaneous transluminal coronary angioplasty 16 months after stress scintigraphy for persisting anginal complaints. Three patients were lost to follow-up; all three had a low pretest likelihood of coronary artery disease. It is concluded that patients with chest pain and normal findings on quantitative thallium-201 scintigraphy have an excellent prognosis. Cardiac events are rare (infarction rate 1% per year) and occur in patients with a moderate to high pretest likelihood of coronary artery disease.},
doi = {10.1016/S0735-1097(85)80247-3},
journal = {J. Am. Coll. Cardiol.; (United States)},
number = ,
volume = 1,
place = {United States},
year = {1985},
month = {7}
}