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Title: Parallel analysis of cancer mortality among atomic bomb survivors and patients with ankylosing spondylitis given X-ray therapy

Abstract

Radiation-induced cancer mortality rates among atomic bomb survivors with doses of at least 100 rad and patients with ankylosing spondylitis given X-ray therapy have been compared for the first time. The estimated average mean bone marrow dose for the spondylitics is more than twice that for atomic bomb survivors, and yet spondylitics experienced only half the risk of radiation-induced leukemia of atomic bomb survivors. For sites that were heavily irradiated in the spondylitics, provisional estimates indicate comparable doses in the two studies, and similar levels of cancer risk were observed. For these sites, when information from the studies was combined, there were statistically significant excesses for cancers of the esophagus, stomach, lung, and ovaries, multiple myeloma, other lymphomas, and tumors of the spinal cord and nerves. Very high relative risks (RR's) for tumors of the spinal cord and nerves were observed in both studies. For sites that were lightly irradiated in the spondylitics, in addition to previously documented sites, there was a statistically significant excess of cancers of the liver and gallbladder among atomic bomb survivors. A previous subdivision of cancer sites into radiosensitive and other tissues was not supported by the atomic bomb survivor data. Changes in the ratesmore » of radiation-induced cancers with age at exposure and time since exposure were studied and compared with the use of generalized linear modeling of the RR's and also by examination of the excess mortality rates. The level of agreement between the two studies was high; provided it is accepted that the reduced level of leukemia risk in the spondylitics is due to cell sterilization, no inconsistencies were found.« less

Authors:
; ;
Publication Date:
Research Org.:
Radiation Effects Research Foundation, Hiroshima, Japan
OSTI Identifier:
5148726
Resource Type:
Journal Article
Journal Name:
J. Natl. Cancer Inst.; (United States)
Additional Journal Information:
Journal Volume: 1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; A-BOMB SURVIVORS; DELAYED RADIATION EFFECTS; RADIATION DOSES; NEOPLASMS; RADIOINDUCTION; RADIOTHERAPY; AGE DEPENDENCE; COMPARATIVE EVALUATIONS; DOSE-RESPONSE RELATIONSHIPS; ESOPHAGUS; JAPAN; LIVER; LUNGS; MORTALITY; NERVES; OVARIES; PATIENTS; RISK ASSESSMENT; SPINAL CORD; STOMACH; TIME DEPENDENCE; WARFARE; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; DIGESTIVE SYSTEM; DISEASES; DOSES; FEMALE GENITALS; GASTROINTESTINAL TRACT; GLANDS; GONADS; HUMAN POPULATIONS; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; POPULATIONS; RADIATION EFFECTS; RADIOLOGY; RESPIRATORY SYSTEM; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Darby, S C, Nakashima, E, and Kato, H. Parallel analysis of cancer mortality among atomic bomb survivors and patients with ankylosing spondylitis given X-ray therapy. United States: N. p., 1985. Web.
Darby, S C, Nakashima, E, & Kato, H. Parallel analysis of cancer mortality among atomic bomb survivors and patients with ankylosing spondylitis given X-ray therapy. United States.
Darby, S C, Nakashima, E, and Kato, H. Mon . "Parallel analysis of cancer mortality among atomic bomb survivors and patients with ankylosing spondylitis given X-ray therapy". United States.
@article{osti_5148726,
title = {Parallel analysis of cancer mortality among atomic bomb survivors and patients with ankylosing spondylitis given X-ray therapy},
author = {Darby, S C and Nakashima, E and Kato, H},
abstractNote = {Radiation-induced cancer mortality rates among atomic bomb survivors with doses of at least 100 rad and patients with ankylosing spondylitis given X-ray therapy have been compared for the first time. The estimated average mean bone marrow dose for the spondylitics is more than twice that for atomic bomb survivors, and yet spondylitics experienced only half the risk of radiation-induced leukemia of atomic bomb survivors. For sites that were heavily irradiated in the spondylitics, provisional estimates indicate comparable doses in the two studies, and similar levels of cancer risk were observed. For these sites, when information from the studies was combined, there were statistically significant excesses for cancers of the esophagus, stomach, lung, and ovaries, multiple myeloma, other lymphomas, and tumors of the spinal cord and nerves. Very high relative risks (RR's) for tumors of the spinal cord and nerves were observed in both studies. For sites that were lightly irradiated in the spondylitics, in addition to previously documented sites, there was a statistically significant excess of cancers of the liver and gallbladder among atomic bomb survivors. A previous subdivision of cancer sites into radiosensitive and other tissues was not supported by the atomic bomb survivor data. Changes in the rates of radiation-induced cancers with age at exposure and time since exposure were studied and compared with the use of generalized linear modeling of the RR's and also by examination of the excess mortality rates. The level of agreement between the two studies was high; provided it is accepted that the reduced level of leukemia risk in the spondylitics is due to cell sterilization, no inconsistencies were found.},
doi = {},
url = {https://www.osti.gov/biblio/5148726}, journal = {J. Natl. Cancer Inst.; (United States)},
number = ,
volume = 1,
place = {United States},
year = {1985},
month = {7}
}