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Title: Methionine adenosyltransferase activity of the rat liver under the influence of x-rays and the thioposphamide

Abstract

One group of rats was exposed to a total-body dose of 600R of x radiation and the animals were killed at intervals up to 30 days. A second group of rats was given intravenous injections of thiophosphamide and killed at intervals up to 10 days. Activity of methionine adenosyltransferase (MAT) in the liver was then assayed. There was a significant decrease in MAT activity 3 days following irradiation; in surviving animals the activity was normal after 30 days. Three days following administration of thiophosphamide there was an increase of enzyme activity; this was followed by a significant drop after 7 days. (HLW)

Authors:
;
Publication Date:
Research Org.:
Odessa Medical Inst.
OSTI Identifier:
5134202
Resource Type:
Journal Article
Journal Name:
Radiobiology (USSR) (Engl. Transl.); (United States)
Additional Journal Information:
Journal Volume: 17:5; Other Information: Translated from Radiobiologiya; 17: No. 5, 776-779(1977)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RADIOMIMETIC DRUGS; BIOLOGICAL EFFECTS; TRANSFERASES; BIOLOGICAL RADIATION EFFECTS; METABOLISM; LIVER; RATS; X RADIATION; ANIMALS; BODY; DIGESTIVE SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; ENZYMES; GLANDS; IONIZING RADIATIONS; MAMMALS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Zelinskii, V G, and Savitskii, I V. Methionine adenosyltransferase activity of the rat liver under the influence of x-rays and the thioposphamide. United States: N. p., 1977. Web.
Zelinskii, V G, & Savitskii, I V. Methionine adenosyltransferase activity of the rat liver under the influence of x-rays and the thioposphamide. United States.
Zelinskii, V G, and Savitskii, I V. Sat . "Methionine adenosyltransferase activity of the rat liver under the influence of x-rays and the thioposphamide". United States.
@article{osti_5134202,
title = {Methionine adenosyltransferase activity of the rat liver under the influence of x-rays and the thioposphamide},
author = {Zelinskii, V G and Savitskii, I V},
abstractNote = {One group of rats was exposed to a total-body dose of 600R of x radiation and the animals were killed at intervals up to 30 days. A second group of rats was given intravenous injections of thiophosphamide and killed at intervals up to 10 days. Activity of methionine adenosyltransferase (MAT) in the liver was then assayed. There was a significant decrease in MAT activity 3 days following irradiation; in surviving animals the activity was normal after 30 days. Three days following administration of thiophosphamide there was an increase of enzyme activity; this was followed by a significant drop after 7 days. (HLW)},
doi = {},
url = {https://www.osti.gov/biblio/5134202}, journal = {Radiobiology (USSR) (Engl. Transl.); (United States)},
number = ,
volume = 17:5,
place = {United States},
year = {1977},
month = {1}
}