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Title: Evaluation of 3D reconstruction algorithms for a small animal PET camera

Abstract

The use of paired, opposing position-sensitive phototube scintillation cameras (SCs) operating in coincidence for small animal imaging with positron emitters is currently under study. Because of the low sensitivity of the system even in 3D mode and the need to produce images with high resolution, it was postulated that a 3D expectation maximization (EM) reconstruction algorithm might be well suited for this application. We investigated four reconstruction algorithms for the 3D SC PET camera: 2D filtered back-projection (FBP), 2D ordered subset EM (OSEM), 3D reprojection (3DRP), and 3D OSEM. Noise was assessed for all slices by the coefficient of variation in a simulated uniform cylinder. Resolution was assessed from a simulation of 15 point sources in the warm background of the uniform cylinder. At comparable noise levels, the resolution achieved with OSEM (0.9-mm to 1.2-mm) is significantly better than that obtained with FBP or 3DRP (1.5-mm to 2.0-mm.) Images of a rat skull labeled with {sup 18}F-fluoride suggest that 3D OSEM can improve image quality of a small animal PET camera.

Authors:
; ;  [1]
  1. National Institutes of Health, Bethesda, MD (United States); and others
Publication Date:
OSTI Identifier:
513236
Report Number(s):
CONF-961123-
TRN: 97:014289
Resource Type:
Conference
Resource Relation:
Conference: Institute of Electrical and Electronic Engineers (IEEE) nuclear science symposium and medical imaging conference, Anaheim, CA (United States), 2-9 Nov 1996; Other Information: PBD: 1996; Related Information: Is Part Of 1996 IEEE nuclear science symposium - conference record. Volumes 1, 2 and 3; Del Guerra, A. [ed.]; PB: 2138 p.
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 44 INSTRUMENTATION, INCLUDING NUCLEAR AND PARTICLE DETECTORS; POSITRON COMPUTED TOMOGRAPHY; ALGORITHMS; ANIMALS; POSITION SENSITIVE DETECTORS; SPATIAL RESOLUTION; PHOTOMULTIPLIERS; SOLID SCINTILLATION DETECTORS

Citation Formats

Johnson, C A, Gandler, W R, and Seidel, J. Evaluation of 3D reconstruction algorithms for a small animal PET camera. United States: N. p., 1996. Web.
Johnson, C A, Gandler, W R, & Seidel, J. Evaluation of 3D reconstruction algorithms for a small animal PET camera. United States.
Johnson, C A, Gandler, W R, and Seidel, J. 1996. "Evaluation of 3D reconstruction algorithms for a small animal PET camera". United States.
@article{osti_513236,
title = {Evaluation of 3D reconstruction algorithms for a small animal PET camera},
author = {Johnson, C A and Gandler, W R and Seidel, J},
abstractNote = {The use of paired, opposing position-sensitive phototube scintillation cameras (SCs) operating in coincidence for small animal imaging with positron emitters is currently under study. Because of the low sensitivity of the system even in 3D mode and the need to produce images with high resolution, it was postulated that a 3D expectation maximization (EM) reconstruction algorithm might be well suited for this application. We investigated four reconstruction algorithms for the 3D SC PET camera: 2D filtered back-projection (FBP), 2D ordered subset EM (OSEM), 3D reprojection (3DRP), and 3D OSEM. Noise was assessed for all slices by the coefficient of variation in a simulated uniform cylinder. Resolution was assessed from a simulation of 15 point sources in the warm background of the uniform cylinder. At comparable noise levels, the resolution achieved with OSEM (0.9-mm to 1.2-mm) is significantly better than that obtained with FBP or 3DRP (1.5-mm to 2.0-mm.) Images of a rat skull labeled with {sup 18}F-fluoride suggest that 3D OSEM can improve image quality of a small animal PET camera.},
doi = {},
url = {https://www.osti.gov/biblio/513236}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 31 00:00:00 EST 1996},
month = {Tue Dec 31 00:00:00 EST 1996}
}

Conference:
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