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Title: Imaging experimental infective endocarditis with indium-111-labeled blood cellular components

Abstract

The capability of radionuclide imaging to detect experimental aortic valve infective endocarditis was assessed with indium-111 (/sup 111/In)-labeled blood cells. Sequential cardiac imaging and tissue distribution studies were obtained in 17 rabbits with infective endocarditis after administration of /sup 111/-In-platelets and in five after /sup 111/In-polymorphonuclear leukocytes. Forty-eight to 72 hours after platelet administration, in vivo imaging demonstrated abnormal /sup 111/In uptake in all animals in the region of the aortic valve in an anatomically distinct pattern. Images of the excised heart showed discrete cardiac uptake conforming to the in vivo image and gross pathological examination. /sup 111/In platelet uptake in vegetations from the 17 animals averaged 240 +- 41 times greater than that in normal myocardium and 99 +- 15 times greater uptake in blood. In contrast, /sup 111/In-leukocyte cardiac imaging showed no abnormal aortic valve uptake 24 hours after tracer administration and the lesion myocardium activity ratio was only 5 +- 2 (3 +- 1 for lesion/blood activity). Four normal rabbits demonstrated neither positive /sup 111/In platelet scintigraphs nor abnormal cardiac tissue uptake. Likewise, noncellular /sup 111/In was not concentrated to any significant extent in three animals with infective endocarditis.This study demonstrates that /sup 111/In platelet, but notmore » leukocyte cardiac imaging, is a sensitive technique for detecting experimental infective endocarditis. The imaging data conform to the cellular pathology of the infective endocarditis vegetation.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Yale Univ. School of Medicine, New Haven, CT
OSTI Identifier:
5126898
DOE Contract Number:  
EY-76-S-02-4078
Resource Type:
Journal Article
Journal Name:
Circulation; (United States)
Additional Journal Information:
Journal Volume: 59:2
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; AORTA; SCINTISCANNING; CARDIOVASCULAR DISEASES; DIAGNOSIS; HEART; INDIUM 111; DIAGNOSTIC USES; INFLAMMATION; BLOOD PLATELETS; COMPARATIVE EVALUATIONS; INFECTIOUS DISEASES; LABELLED COMPOUNDS; LEUKOCYTES; RABBITS; TISSUE DISTRIBUTION; ANIMALS; ARTERIES; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BLOOD VESSELS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPE SCANNING; RADIOISOTOPES; USES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 551000 - Physiological Systems

Citation Formats

Riba, A.L., Thakur, M.L., Gottschalk, A., Andriole, V.T., and Zaret, B.L. Imaging experimental infective endocarditis with indium-111-labeled blood cellular components. United States: N. p., 1979. Web. doi:10.1161/01.CIR.59.2.336.
Riba, A.L., Thakur, M.L., Gottschalk, A., Andriole, V.T., & Zaret, B.L. Imaging experimental infective endocarditis with indium-111-labeled blood cellular components. United States. doi:10.1161/01.CIR.59.2.336.
Riba, A.L., Thakur, M.L., Gottschalk, A., Andriole, V.T., and Zaret, B.L. Thu . "Imaging experimental infective endocarditis with indium-111-labeled blood cellular components". United States. doi:10.1161/01.CIR.59.2.336.
@article{osti_5126898,
title = {Imaging experimental infective endocarditis with indium-111-labeled blood cellular components},
author = {Riba, A.L. and Thakur, M.L. and Gottschalk, A. and Andriole, V.T. and Zaret, B.L.},
abstractNote = {The capability of radionuclide imaging to detect experimental aortic valve infective endocarditis was assessed with indium-111 (/sup 111/In)-labeled blood cells. Sequential cardiac imaging and tissue distribution studies were obtained in 17 rabbits with infective endocarditis after administration of /sup 111/-In-platelets and in five after /sup 111/In-polymorphonuclear leukocytes. Forty-eight to 72 hours after platelet administration, in vivo imaging demonstrated abnormal /sup 111/In uptake in all animals in the region of the aortic valve in an anatomically distinct pattern. Images of the excised heart showed discrete cardiac uptake conforming to the in vivo image and gross pathological examination. /sup 111/In platelet uptake in vegetations from the 17 animals averaged 240 +- 41 times greater than that in normal myocardium and 99 +- 15 times greater uptake in blood. In contrast, /sup 111/In-leukocyte cardiac imaging showed no abnormal aortic valve uptake 24 hours after tracer administration and the lesion myocardium activity ratio was only 5 +- 2 (3 +- 1 for lesion/blood activity). Four normal rabbits demonstrated neither positive /sup 111/In platelet scintigraphs nor abnormal cardiac tissue uptake. Likewise, noncellular /sup 111/In was not concentrated to any significant extent in three animals with infective endocarditis.This study demonstrates that /sup 111/In platelet, but not leukocyte cardiac imaging, is a sensitive technique for detecting experimental infective endocarditis. The imaging data conform to the cellular pathology of the infective endocarditis vegetation.},
doi = {10.1161/01.CIR.59.2.336},
journal = {Circulation; (United States)},
number = ,
volume = 59:2,
place = {United States},
year = {1979},
month = {2}
}