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Title: Gastric emptying abnormal in duodenal ulcer

Abstract

To investigate the possibility that an abnormality of gastric emptying exists in duodenal ulcer and to determine if such an abnormality persists after ulcer healing, scintigraphic gastric emptying measurements were undertaken in 16 duodenal ulcer patients before, during, and after therapy with cimetidine; in 12 patients with pernicious anemia, and in 12 control subjects. No difference was detected in the rate or pattern of gastric emptying in duodenal ulcer patients before and after ulcer healing with cimetidine compared with controls, but emptying of the solid component of the test meal was more rapid during treatment with the drug. Comparison of emptying patterns obtained in duodenal ulcer subjects during and after cimetidine treatment with those obtained in pernicious anemia patients and controls revealed a similar relationship that was characterized by a tendency for reduction in the normal differentiation between the emptying of solid and liquid from the stomach. The similarity in emptying patterns in these groups of subjects suggests that gastric emptying of solids may be influenced by changes in the volume of gastric secretion. The failure to detect an abnormality of gastric emptying in duodenal ulcer subjects before and after ulcer healing calls into question the widespread belief that abnormallymore » rapid gastric emptying is a feature with pathogenetic significance in duodenal ulcer disease.« less

Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
5124614
Resource Type:
Journal Article
Resource Relation:
Journal Name: Dig. Dis. Sci.; (United States); Journal Volume: 7
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; STOMACH; SCINTISCANNING; ULCERS; PATHOGENESIS; DYNAMIC FUNCTION STUDIES; INDIUM 111; BETA DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; GASTROINTESTINAL TRACT; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPE SCANNING; RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Holt, S., Heading, R.C., Taylor, T.V., Forrest, J.A., and Tothill, P. Gastric emptying abnormal in duodenal ulcer. United States: N. p., 1986. Web. doi:10.1007/BF01296444.
Holt, S., Heading, R.C., Taylor, T.V., Forrest, J.A., & Tothill, P. Gastric emptying abnormal in duodenal ulcer. United States. doi:10.1007/BF01296444.
Holt, S., Heading, R.C., Taylor, T.V., Forrest, J.A., and Tothill, P. Tue . "Gastric emptying abnormal in duodenal ulcer". United States. doi:10.1007/BF01296444.
@article{osti_5124614,
title = {Gastric emptying abnormal in duodenal ulcer},
author = {Holt, S. and Heading, R.C. and Taylor, T.V. and Forrest, J.A. and Tothill, P.},
abstractNote = {To investigate the possibility that an abnormality of gastric emptying exists in duodenal ulcer and to determine if such an abnormality persists after ulcer healing, scintigraphic gastric emptying measurements were undertaken in 16 duodenal ulcer patients before, during, and after therapy with cimetidine; in 12 patients with pernicious anemia, and in 12 control subjects. No difference was detected in the rate or pattern of gastric emptying in duodenal ulcer patients before and after ulcer healing with cimetidine compared with controls, but emptying of the solid component of the test meal was more rapid during treatment with the drug. Comparison of emptying patterns obtained in duodenal ulcer subjects during and after cimetidine treatment with those obtained in pernicious anemia patients and controls revealed a similar relationship that was characterized by a tendency for reduction in the normal differentiation between the emptying of solid and liquid from the stomach. The similarity in emptying patterns in these groups of subjects suggests that gastric emptying of solids may be influenced by changes in the volume of gastric secretion. The failure to detect an abnormality of gastric emptying in duodenal ulcer subjects before and after ulcer healing calls into question the widespread belief that abnormally rapid gastric emptying is a feature with pathogenetic significance in duodenal ulcer disease.},
doi = {10.1007/BF01296444},
journal = {Dig. Dis. Sci.; (United States)},
number = ,
volume = 7,
place = {United States},
year = {Tue Jul 01 00:00:00 EDT 1986},
month = {Tue Jul 01 00:00:00 EDT 1986}
}