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Title: Lung damage and pulmonary uptake of serotonin in intact dogs

Abstract

The authors examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of (/sup 3/H)serotonin and the extravascular volume accessible to (/sup 14/C)antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin uptake by 53 and 61%, respectively, but no change was observed with oleic acid or dextran infusion. The extravascular volume accessible to the antipyrine was reduced by 77% after embolization and increased by 177 and approximately 44% after oleic acid and dextran infusion, respectively. The results suggest that when the perfused endothelial surface is sufficiently reduced, as with embolization, the uptake of trace doses of serotonin will be depressed. In addition, decreases in serotonin uptake in response to imipramine in this study and in response to certain endothelial toxins in other studies suggest that serotonin uptake can reveal certain kinds of changes in endothelial function. However, the lack of a response to oleic acid-induced damage in the present study suggests that serotonin uptake is not sensitive to all forms of endothelial damage.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Veterans Administration Medical Center, Wood, WI
OSTI Identifier:
5118909
Resource Type:
Journal Article
Journal Name:
J. Appl. Physiol.; (United States)
Additional Journal Information:
Journal Volume: 6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; DEXTRAN; BIOLOGICAL EFFECTS; IMIPRAMINE; TOXICITY; LUNGS; INJURIES; OLEIC ACID; SEROTONIN; UPTAKE; ANTIPYRINE; CARBON 14 COMPOUNDS; DOGS; ENDOTHELIUM; EXTRACELLULAR SPACE; INDOCYANINE GREEN; RESPIRATORY SYSTEM DISEASES; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AMINES; ANIMAL TISSUES; ANIMALS; ANTIDEPRESSANTS; ANTIPYRETICS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BLOOD SUBSTITUTES; BODY; CARBOHYDRATES; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONDENSED AROMATICS; DISEASES; DRUGS; DYES; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDICATORS; INDOLES; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; MONOCARBOXYLIC ACIDS; NEUROREGULATORS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; POLYSACCHARIDES; PSYCHOTROPIC DRUGS; PYRAZOLES; PYRAZOLINES; PYRROLES; RADIOPROTECTIVE SUBSTANCES; RESPIRATORY SYSTEM; SACCHARIDES; SPACE; SULFONATES; SYMPATHOMIMETICS; TISSUES; TRYPTAMINES; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550501 - Metabolism- Tracer Techniques

Citation Formats

Dawson, C A, Christensen, C W, Rickaby, D A, Linehan, J H, and Johnston, M R. Lung damage and pulmonary uptake of serotonin in intact dogs. United States: N. p., 1985. Web.
Dawson, C A, Christensen, C W, Rickaby, D A, Linehan, J H, & Johnston, M R. Lung damage and pulmonary uptake of serotonin in intact dogs. United States.
Dawson, C A, Christensen, C W, Rickaby, D A, Linehan, J H, and Johnston, M R. 1985. "Lung damage and pulmonary uptake of serotonin in intact dogs". United States.
@article{osti_5118909,
title = {Lung damage and pulmonary uptake of serotonin in intact dogs},
author = {Dawson, C A and Christensen, C W and Rickaby, D A and Linehan, J H and Johnston, M R},
abstractNote = {The authors examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of (/sup 3/H)serotonin and the extravascular volume accessible to (/sup 14/C)antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin uptake by 53 and 61%, respectively, but no change was observed with oleic acid or dextran infusion. The extravascular volume accessible to the antipyrine was reduced by 77% after embolization and increased by 177 and approximately 44% after oleic acid and dextran infusion, respectively. The results suggest that when the perfused endothelial surface is sufficiently reduced, as with embolization, the uptake of trace doses of serotonin will be depressed. In addition, decreases in serotonin uptake in response to imipramine in this study and in response to certain endothelial toxins in other studies suggest that serotonin uptake can reveal certain kinds of changes in endothelial function. However, the lack of a response to oleic acid-induced damage in the present study suggests that serotonin uptake is not sensitive to all forms of endothelial damage.},
doi = {},
url = {https://www.osti.gov/biblio/5118909}, journal = {J. Appl. Physiol.; (United States)},
number = ,
volume = 6,
place = {United States},
year = {Sat Jun 01 00:00:00 EDT 1985},
month = {Sat Jun 01 00:00:00 EDT 1985}
}