skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Radionuclide administration to nursing mothers: mathematically derived guidelines

Abstract

We determined a formula to establish objective guidelines for the administration of radionuclides to nursing mothers. The formula is based on the maximum permissible dose to the infant's critical organ, serial measurements of breast milk activity, milk volume, and dose to the critical organ per microcurie in milk. Using worst-case assumptions, we believe that cessation of nursing for 24 hours after administration of technetium labeled radiopharmaceuticals is sufficient for safety. Longer-lived agents require greater delays. Iodine-123 radiopharmaceuticals are preferable to iodine-131 agents and should always be used when studying the unblocked thyroid.

Authors:
; ; ;
Publication Date:
OSTI Identifier:
5118473
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiology; (United States); Journal Volume: 2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; RADIONUCLIDE ADMINISTRATION; WOMEN; INFANTS; IODINE 123; IODINE 131; LACTATION; MILK; PREGNANCY; RADIATION DOSES; RADIOPHARMACEUTICALS; RECOMMENDATIONS; TECHNETIUM 99; AGE GROUPS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY FLUIDS; CHILDREN; DAYS LIVING RADIOISOTOPES; DOSES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; FEMALES; FOOD; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MAN; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; PRIMATES; RADIOISOTOPES; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man; 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Romney, B.M., Nickoloff, E.L., Esser, P.D., and Alderson, P.O.. Radionuclide administration to nursing mothers: mathematically derived guidelines. United States: N. p., 1986. Web. doi:10.1148/radiology.160.2.3726137.
Romney, B.M., Nickoloff, E.L., Esser, P.D., & Alderson, P.O.. Radionuclide administration to nursing mothers: mathematically derived guidelines. United States. doi:10.1148/radiology.160.2.3726137.
Romney, B.M., Nickoloff, E.L., Esser, P.D., and Alderson, P.O.. Fri . "Radionuclide administration to nursing mothers: mathematically derived guidelines". United States. doi:10.1148/radiology.160.2.3726137.
@article{osti_5118473,
title = {Radionuclide administration to nursing mothers: mathematically derived guidelines},
author = {Romney, B.M. and Nickoloff, E.L. and Esser, P.D. and Alderson, P.O.},
abstractNote = {We determined a formula to establish objective guidelines for the administration of radionuclides to nursing mothers. The formula is based on the maximum permissible dose to the infant's critical organ, serial measurements of breast milk activity, milk volume, and dose to the critical organ per microcurie in milk. Using worst-case assumptions, we believe that cessation of nursing for 24 hours after administration of technetium labeled radiopharmaceuticals is sufficient for safety. Longer-lived agents require greater delays. Iodine-123 radiopharmaceuticals are preferable to iodine-131 agents and should always be used when studying the unblocked thyroid.},
doi = {10.1148/radiology.160.2.3726137},
journal = {Radiology; (United States)},
number = ,
volume = 2,
place = {United States},
year = {Fri Aug 01 00:00:00 EDT 1986},
month = {Fri Aug 01 00:00:00 EDT 1986}
}