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Title: Short-term tests of genotoxicity for 1,1,1-trichloroethane

Abstract

Covalent binding of /sup 14/C-1,1,1-trichloroethane to macromolecules from rat and mouse liver, kidney, lung and stomach was analyzed under the same experimental conditions previously utilized in studying 1,1-dichloroethane and 1,1,2-trichloroethane. Labeling of DNA, RNA and proteins was very low both in in vivo interaction and in in vitro microsome-mediated binding. Interaction proceeded through the involvement of the P-450-dependent mixed function oxidase system from liver microsomes and, to a lesser extent, from lung microsomes. Covalent Binding Index of 1,1,1-trichloroethane in liver DNA was typical of very weak initiators. However, overall evaluation of the short-term assays available for 1,1,1-trichloroethane leads to limited evidence of genotoxicity. On the other hand, the evidence of 1,1,1-trichloroethane carcinogenicity in animals is still inadequate.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Universita di Bologna, Italy
OSTI Identifier:
5116405
Resource Type:
Journal Article
Journal Name:
Res. Commun. Chem. Pathol. Pharmacol.; (United States)
Additional Journal Information:
Journal Volume: 3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; CHLORINATED ALIPHATIC HYDROCARBONS; TOXICITY; CARBON 14 COMPOUNDS; CHEMICAL BONDS; DNA; KIDNEYS; LIVER; LUNGS; MICE; MICROSOMES; MIXED-FUNCTION OXIDASES; PROTEINS; RATS; RNA; SOLVENTS; STOMACH; TRACER TECHNIQUES; ANIMALS; BODY; CELL CONSTITUENTS; DIGESTIVE SYSTEM; ENZYMES; GASTROINTESTINAL TRACT; GLANDS; HALOGENATED ALIPHATIC HYDROCARBONS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; NUCLEIC ACIDS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANOIDS; ORGANS; OXIDOREDUCTASES; OXYGENASES; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550201 - Biochemistry- Tracer Techniques

Citation Formats

Turina, M.P., Colacci, A., Grilli, S., Mazzullo, M., Prodi, G., and Lattanzi, G. Short-term tests of genotoxicity for 1,1,1-trichloroethane. United States: N. p., 1986. Web.
Turina, M.P., Colacci, A., Grilli, S., Mazzullo, M., Prodi, G., & Lattanzi, G. Short-term tests of genotoxicity for 1,1,1-trichloroethane. United States.
Turina, M.P., Colacci, A., Grilli, S., Mazzullo, M., Prodi, G., and Lattanzi, G. Sun . "Short-term tests of genotoxicity for 1,1,1-trichloroethane". United States.
@article{osti_5116405,
title = {Short-term tests of genotoxicity for 1,1,1-trichloroethane},
author = {Turina, M.P. and Colacci, A. and Grilli, S. and Mazzullo, M. and Prodi, G. and Lattanzi, G.},
abstractNote = {Covalent binding of /sup 14/C-1,1,1-trichloroethane to macromolecules from rat and mouse liver, kidney, lung and stomach was analyzed under the same experimental conditions previously utilized in studying 1,1-dichloroethane and 1,1,2-trichloroethane. Labeling of DNA, RNA and proteins was very low both in in vivo interaction and in in vitro microsome-mediated binding. Interaction proceeded through the involvement of the P-450-dependent mixed function oxidase system from liver microsomes and, to a lesser extent, from lung microsomes. Covalent Binding Index of 1,1,1-trichloroethane in liver DNA was typical of very weak initiators. However, overall evaluation of the short-term assays available for 1,1,1-trichloroethane leads to limited evidence of genotoxicity. On the other hand, the evidence of 1,1,1-trichloroethane carcinogenicity in animals is still inadequate.},
doi = {},
journal = {Res. Commun. Chem. Pathol. Pharmacol.; (United States)},
number = ,
volume = 3,
place = {United States},
year = {1986},
month = {6}
}