Aerosol penetration ratio: a new index of ventilation

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · J. Nucl. Med.; (United States)

OSTI ID:5094774

Sirr, S A; Elliott, G R; Regelmann, W E; Juenemann, P J; Morin, R L; Boudreau, R J; Warwick, W J; Loken, M K

Superimposition of nuclear medicine scintigrams and standard radiographs provides a unique opportunity for merging functional information intrinsic to nuclear medicine images with the high resolution anatomic detail of radiographs. A newly developed image processing system allows the merging of two separate films of greatly varying sizes to form a single composite image. Subsequent quantitative analysis of the composite image may be performed. Using the superimposition technique, (/sup 99m/Tc)DTPA aerosol ventilation scans (4.5 X 4.5 cm) were superimposed upon chest radiographs (35.6 X 43.2 cm) in 17 cystic fibrosis (CF) patients. Subsequent quantification of the area of nuclear scan ventilation and the radiographic lung area was then performed. A new quantitative radiologic index of ventilation, the aerosol penetration ratio (APR), was defined. Linear correlation of aerosol penetration ratio with residual volume (RV) as percent of total lung capacity (TLC) measured by body plethysmography was good. We conclude that the APR has validity as a physiologic parameter which localized regional excessive residual volume and correlates well with RV/TLC, the gold standard pulmonary function index of obstructive airway disease.

• Research Organization: Univ. of Minnesota School of Medicine, Minneapolis
• OSTI ID: 5094774
• Journal Information: J. Nucl. Med.; (United States), Vol. 8
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LUNGS
SCINTISCANNING
IMAGE PROCESSING
BIOMEDICAL RADIOGRAPHY
DTPA
INHALATION
PATIENTS
RADIOACTIVE AEROSOLS
RESPIRATORY SYSTEM DISEASES
TECHNETIUM 99
AEROSOLS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
DRUGS
HOURS LIVING RADIOISOTOPES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SOLS
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics