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Title: Radiation-induced accelerated coronary arteriosclerosis

Abstract

There is a paucity of information on radiation-induced coronary heart disease. A young patient with myocardial infarction following mediastinal irradiation is described. The role of radiotherapy and chemotherapy on the subsequent development of coronary heart disease is discussed.

Authors:
; ; ;
Publication Date:
OSTI Identifier:
5091218
Resource Type:
Journal Article
Resource Relation:
Journal Name: Am. J. Med.; (United States); Journal Volume: 1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; CARDIOVASCULAR DISEASES; RADIOINDUCTION; HEART; BIOLOGICAL RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; ARTERIOSCLEROSIS; MEDIASTINUM; PATIENTS; BIOLOGICAL EFFECTS; BODY; BODY AREAS; CARDIOVASCULAR SYSTEM; CHEST; DISEASES; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY; VASCULAR DISEASES; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Mittal, B., Deutsch, M., Thompson, M., and Dameshek, H.L. Radiation-induced accelerated coronary arteriosclerosis. United States: N. p., 1986. Web. doi:10.1016/0002-9343(86)90208-1.
Mittal, B., Deutsch, M., Thompson, M., & Dameshek, H.L. Radiation-induced accelerated coronary arteriosclerosis. United States. doi:10.1016/0002-9343(86)90208-1.
Mittal, B., Deutsch, M., Thompson, M., and Dameshek, H.L. 1986. "Radiation-induced accelerated coronary arteriosclerosis". United States. doi:10.1016/0002-9343(86)90208-1.
@article{osti_5091218,
title = {Radiation-induced accelerated coronary arteriosclerosis},
author = {Mittal, B. and Deutsch, M. and Thompson, M. and Dameshek, H.L.},
abstractNote = {There is a paucity of information on radiation-induced coronary heart disease. A young patient with myocardial infarction following mediastinal irradiation is described. The role of radiotherapy and chemotherapy on the subsequent development of coronary heart disease is discussed.},
doi = {10.1016/0002-9343(86)90208-1},
journal = {Am. J. Med.; (United States)},
number = ,
volume = 1,
place = {United States},
year = 1986,
month = 7
}
  • Thirty-nine adult male beagles received either fast neutron or photon irradiation to the right thorax to obtain values for the relative biological effectiveness (RBE) of fast neutrons as assessed by quantitative parameters of lung function. Fast neutrons (15 MeV avg.) were delivered in 4 fx/wk for six weeks to total doses of 1000, 1500, 2250, or 3375 rad while the photon irradiated dogs received total doses of 3000, 4500, or 6750 rad in the same fractionation schedule. The right atrium and coronary groove of the heart were included in the irradiated field. Cholesterol levels (and triglyceride levels when obtainable) weremore » measured prior to irradiation and every three months until death. Arteries were graded (0, negative to 5, severe) for endothelial proliferation, disruption and duplication of the elastic lamina, perivascular fibrosis and the presence of foamy macrophages. All dogs that survived 75 days post-irradiation developed arterial changes; two neutron irradiated dogs showed severe atherosclerotic plaque formation. Data suggest an RBE between 4 and 5.« less
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