Tissue disposition of zinc and copper following repeated administration of cadmium and selenium to rats

Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(85)90123-9· OSTI ID:5091055

Chmielnicka, J; Bem, E M; Brzeznicka, E A; Kasperek, M

Female rats were divided into four groups of five rats each including one control group (C). The animals were administered Na/sub 2/SeO/sub 3/ (Se), (CdCl/sub 2/Cd), and Na/sub 2/SeO/sub 3/ + CdCl/sub 2/ (Cd +Se). Sodium selenite was given intragastrically at a dose of 0.5 mg Se/kg every day and cadmium chloride was injected subcutaneously every other day at a dose of 0.3 mg Cd/kg for 2 weeks. Exposure of rats to Cd caused an increase in the concentration of copper in the kidneys, blood, and liver and a decrease in the lung, but increased the concentration of zinc in the liver and brain and diminished it in the muscles and bones. In animals exposed to Se an increase in the copper concentration was observed in blood and brain; zinc was increased in the blood, heart, brain, and stomach, but decreased in the kidneys. Exposure of rats to Cd + Se resulted in an increase of copper in the kidneys and a decrease in the spleen, lungs, stomach, muscles and bones. Se prevented the cadmium-induced diminution of the zinc levels in the muscles and bones.

• Research Organization: Institute of Environmental Research and Bioanalysis, Narutowicza, Poland
• OSTI ID: 5091055
• Journal Information: Environ. Res.; (United States), Vol. 37:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
TOXICITY
COPPER
METABOLISM
TISSUE DISTRIBUTION
SELENIUM
BIOLOGICAL EFFECTS
ZINC
BLOOD
BRAIN
EXPERIMENTAL DATA
KIDNEYS
LIVER
LUNGS
MUSCLES
RATS
SKELETON
STOMACH
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
GASTROINTESTINAL TRACT
GLANDS
INFORMATION
MAMMALS
MATERIALS
METALS
NERVOUS SYSTEM
NUMERICAL DATA
ORGANS
RESPIRATORY SYSTEM
RODENTS
SEMIMETALS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)