Radioprotective effect of polyethylene glycol
Polyethylene glycol of molecular weight 400 (PEG-400) had a radioprotective effect of about 20% against lethality when given ip 20 min prior to single or fractionated X-ray doses to the head and neck. Dose modification factors (DMF) based on LD50/15 values ranged from 1.14 to 1.24. A similar DMF of 1.12 based on LD50/30 values was obtained using single doses of whole-body X irradiation. Mice given head and neck irradiation had significantly reduced rectal temperatures (31.3 +/- 3.0/sup 0/C) 9 days post irradiation compared with unirradiated controls (35.4 +/- 0.6/sup 0/C). No such reduction was observed when PEG-400 was given with radiation (36.3 +/- 0.9/sup 0/C). PEG-400 also lessened, but not significantly, the frequency of shivering in irradiated animals. Histopathologic examination of the oral structures demonstrated only marginal protection by PEG-400. Estimation of the alpha/beta ratio from LD50 data on head and neck-irradiated mice yielded values of 4.4 +/- 1.9 (95% confidence limits) Gy without PEG-400 and 7.9 +/- 1.4 Gy with PEG-400. Since it is a non-thiol radioprotector, PEG-400 may be more useful when combined with more conventional thiol-containing radioprotectors.
- Research Organization:
- Eastern Virginia Medical School, Norfolk
- OSTI ID:
- 5090979
- Journal Information:
- Radiat. Res.; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MICE
RADIATION PROTECTION
POLYETHYLENE GLYCOLS
RADIOSENSITIVITY EFFECTS
BIOLOGICAL RADIATION EFFECTS
HEAD
NECK
SYMPTOMS
X RADIATION
ALCOHOLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
ELECTROMAGNETIC RADIATION
GLYCOLS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
POLYMERS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals