Skeletal fluorosis: roentgenological and histopathological study
Detailed radiological and morphometrical studies have been reported in 100 patients of proven endemic skeletal fluorosis all of whom were symptomatic. Though the radiological features such as osteopetrosis, periosteal bone formation, osteophytosis and calcification of the interosseous membrane and ligaments remain the mainstay in the diagnosis of skeletal fluorosis, in increasing instances radiological findings have been variable and uncommon suggesting the presence of other metabolic bone disease. Morphometrical measurements of the iliac crest biopsies revealed osteoclastic resorption of the trabecular bone, increased numbers of resorption lacunae, periosteocytic osteolysis and increased osteoid covered surfaces. The calcification front had a normal distribution except in four patients with associated osteomalacia. Findings were similar in children suffering from endemic fluorosis. These studies suggest that the stabilizing effect of fluoride on bone due to the conversion of hydroxyapatite to fluorapatite produces a compensatory hyperplasia of the parathyroid glands. Thus, the possibility of a beneficial effect of fluoride in osteoporosis has been challenged in the light of this parathyroid compensation.
- Research Organization:
- Medical College, Meerut, India
- OSTI ID:
- 5089966
- Journal Information:
- Fluoride; (United States), Vol. 9:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
FLUORIDES
BIOLOGICAL EFFECTS
LIGAMENTS
CALCINOSIS
SKELETAL DISEASES
DIAGNOSIS
SKELETON
BIOMEDICAL RADIOGRAPHY
CHILDREN
INDIA
OSTEOPOROSIS
PARATHYROID GLANDS
PATIENTS
PELVIS
AGE GROUPS
ANIMAL TISSUES
ASIA
BODY
BODY AREAS
CONNECTIVE TISSUE
DEVELOPING COUNTRIES
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE GLANDS
FLUORINE COMPOUNDS
GLANDS
HALIDES
HALOGEN COMPOUNDS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIOLOGY
TISSUES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
550602 - Medicine- External Radiation in Diagnostics- (1980-)