Diffuse alveolar damage in cats induced by nitrogen dioxide or feline calicivirus
The ultrastructural morphogenesis of pulmonary lesions was studied in cats exposed to either aerosols of feline calicivirus (FCV) or high concentrations of NO/sub 2/. Both directly injured alveolar lining cells, particularly type I cells. Necrosis of pneumocytes attended by an acute exudative response in the air exchange tissues was evident from 0 through 24 hours after exposure of cats to NO/sub 2/ and from 12 through 96 hours after infection with FCV. The reparative process following alveolar injury was characterized by regenerative hyperplasia of type II pneumocytes, proliferation of stromal cells, and infiltration of mononuclear cells. Differences in the lesions produced by NO/sub 2/ and FCV also were encountered. Endothelial necrosis was detected only after NO/sub 2/ injury, whereas a marked infiltration of neutrophils and immunocytes was observed only after FCV injury, the FCV/NO/sub 2/ experimental system in cats is well suited for studies of diffuse alveolar damage of toxic and viral etiology.
- Research Organization:
- Ohio State Univ., Columbus
- OSTI ID:
- 5087067
- Journal Information:
- Am. J. Pathol.; (United States), Vol. 89:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
VIRUSES
AEROSOLS
ANIMAL CELLS
CATS
INFECTIOUS DISEASES
LUNGS
NECROSIS
PATHOLOGICAL CHANGES
TOXICITY
ULTRASTRUCTURAL CHANGES
ANIMALS
BODY
CHALCOGENIDES
COLLOIDS
DISEASES
DISPERSIONS
MAMMALS
MICROORGANISMS
MORPHOLOGICAL CHANGES
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARASITES
RESPIRATORY SYSTEM
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)