Sequential metabolic changes in rat brain following middle cerebral artery occlusion: A 2-deoxyglucose study

Journal Article · Fri Dec 01 00:00:00 EST 1989 · Journal of Cerebral Blood Flow and Metabolism; (USA)

DOI:https://doi.org/10.1038/jcbfm.1989.110· OSTI ID:5081519

Shiraishi, K; Sharp, F R; Simon, R P ^[1]

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1. Univ. of California, San Francisco (USA)

The distribution and time course of altered cerebral metabolism following permanent focal ischemia was studied in rat using the 2-deoxyglucose (2DG) technique. Increased 2DG uptake preceded decreased 2DG uptake and infarction in the caudate putamen and cortex. Decreased 2DG uptake without infarction was observed for 72 h in thalamus and for 24 h in hippocampus (areas remote from the ischemic zones). This study supports the concept of cell excitation as a pathophysiologic process in permanent focal ischemia. The time course of increased metabolism may demarcate the time window of opportunity for the previously demonstrated attenuation of stroke size with inhibition of cell excitation by pharmacologic blockade of excitatory amino acid neurotransmission.

• OSTI ID: 5081519
• Journal Information: Journal of Cerebral Blood Flow and Metabolism; (USA), Vol. 9:6; ISSN 0271-678X
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
GLUCOSE
METABOLISM
ISCHEMIA
PATHOGENESIS
AUTORADIOGRAPHY
CARBON ISOTOPES
CEREBRAL CORTEX
RATS
SPECIFICITY
ALDEHYDES
ANIMALS
BODY
BRAIN
CARBOHYDRATES
CARDIOVASCULAR DISEASES
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CEREBRUM
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ISOTOPES
MAMMALS
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NERVOUS SYSTEM
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ORGANS
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VERTEBRATES
550901* - Pathology- Tracer Techniques