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Title: Brain magnetic resonance imaging with contrast dependent on blood oxygenation

Abstract

Paramagnetic deoxyhemoglobin in venous blood is a naturally occurring contrast agent for magnetic resonance imaging (MRI). By accentuating the effects of this agent through the use of gradient-echo techniques in high yields, the authors demonstrate in vivo images of brain microvasculature with image contrast reflecting the blood oxygen level. This blood oxygenation level-dependent (BOLD) contrast follows blood oxygen changes induced by anesthetics, by insulin-induced hypoglycemia, and by inhaled gas mixtures that alter metabolic demand or blood flow. The results suggest that BOLD contrast can be used to provide in vivo real-time maps of blood oxygenation in the brain under normal physiological conditions. BOLD contrast adds an additional feature to magnetic resonance imaging and complement other techniques that are attempting to provide position emission tomography-like measurements related to regional neural activity.

Authors:
; ; ;  [1]
  1. (AT and T Bell Laboratories, Murray Hill, NJ (United States))
Publication Date:
OSTI Identifier:
5076518
Resource Type:
Journal Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America; (United States)
Additional Journal Information:
Journal Volume: 87:24; Journal Issue: 24; Journal ID: ISSN 0027-8424
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD FLOW; PHYSIOLOGY; BRAIN; NUCLEAR MAGNETIC RESONANCE; CARBON DIOXIDE; HEMOGLOBIN; INSULIN; OXYGEN; RATS; ANIMALS; BODY; CARBON COMPOUNDS; CARBON OXIDES; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; CHALCOGENIDES; ELEMENTS; GLOBINS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HORMONES; MAGNETIC RESONANCE; MAMMALS; NERVOUS SYSTEM; NONMETALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; OXIDES; OXYGEN COMPOUNDS; PEPTIDE HORMONES; PIGMENTS; PORPHYRINS; PROTEINS; RESONANCE; RODENTS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Ogawa, S., Lee, T.M., Kay, A.R., and Tank, D.W. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. United States: N. p., 1990. Web. doi:10.1073/pnas.87.24.9868.
Ogawa, S., Lee, T.M., Kay, A.R., & Tank, D.W. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. United States. doi:10.1073/pnas.87.24.9868.
Ogawa, S., Lee, T.M., Kay, A.R., and Tank, D.W. Sat . "Brain magnetic resonance imaging with contrast dependent on blood oxygenation". United States. doi:10.1073/pnas.87.24.9868.
@article{osti_5076518,
title = {Brain magnetic resonance imaging with contrast dependent on blood oxygenation},
author = {Ogawa, S. and Lee, T.M. and Kay, A.R. and Tank, D.W.},
abstractNote = {Paramagnetic deoxyhemoglobin in venous blood is a naturally occurring contrast agent for magnetic resonance imaging (MRI). By accentuating the effects of this agent through the use of gradient-echo techniques in high yields, the authors demonstrate in vivo images of brain microvasculature with image contrast reflecting the blood oxygen level. This blood oxygenation level-dependent (BOLD) contrast follows blood oxygen changes induced by anesthetics, by insulin-induced hypoglycemia, and by inhaled gas mixtures that alter metabolic demand or blood flow. The results suggest that BOLD contrast can be used to provide in vivo real-time maps of blood oxygenation in the brain under normal physiological conditions. BOLD contrast adds an additional feature to magnetic resonance imaging and complement other techniques that are attempting to provide position emission tomography-like measurements related to regional neural activity.},
doi = {10.1073/pnas.87.24.9868},
journal = {Proceedings of the National Academy of Sciences of the United States of America; (United States)},
issn = {0027-8424},
number = 24,
volume = 87:24,
place = {United States},
year = {1990},
month = {12}
}