Iodine-125-labeled estradiol: a gamma-emitting analog estradiol that binds to the estrogen receptor
Journal Article
·
· Science; (United States)
17..beta..-(16..cap alpha..-/sup 125/I)Iodoestradiol has been synthesized by exchange of 16..beta..-bromoestradiol with Na/sup 125/I. The iodinated product is readily separated from the bromo reactant by column chromatography. It concentrates in the rat uterus in vivo and binds avidly and specifically to the uterine estrogen receptor in vitro.
- Research Organization:
- Columbia Univ., New York, NY
- OSTI ID:
- 5063771
- Journal Information:
- Science; (United States), Vol. 205
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
ESTRADIOL
LABELLING
IODINE 125
RADIOCHEMISTRY
CHEMICAL PREPARATION
LABELLED COMPOUNDS
RATS
TRACER TECHNIQUES
UTERUS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CHEMISTRY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ESTRANES
ESTROGENS
FEMALE GENITALS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
STEROID HORMONES
STEROIDS
SYNTHESIS
VERTEBRATES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
550201 - Biochemistry- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ESTRADIOL
LABELLING
IODINE 125
RADIOCHEMISTRY
CHEMICAL PREPARATION
LABELLED COMPOUNDS
RATS
TRACER TECHNIQUES
UTERUS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CHEMISTRY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ESTRANES
ESTROGENS
FEMALE GENITALS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
STEROID HORMONES
STEROIDS
SYNTHESIS
VERTEBRATES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
550201 - Biochemistry- Tracer Techniques