Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging
Abstract
Cyclo agents are described which are useful in forming antibody-metal conjugates which are used for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2diamino cyclohexane-N,N,N',N'-tetra acetic acid. No Drawings
- Inventors:
- Publication Date:
- OSTI Identifier:
- 5043183
- Patent Number(s):
- US 5292938; A
- Application Number:
- PPN: US 7-867533
- Assignee:
- Associated Universities, Inc., Washington, DC (United States)
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 13 Apr 1992
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; CHELATING AGENTS; CHEMICAL PREPARATION; EMISSION COMPUTED TOMOGRAPHY; RADIOIMMUNOASSAY; RADIOIMMUNOTHERAPY; RADIOPHARMACEUTICALS; BIOASSAY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; IMMUNOASSAY; IMMUNOTHERAPY; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MEDICINE; NUCLEAR MEDICINE; RADIOASSAY; RADIOIMMUNODETECTION; RADIOLOGY; RADIOTHERAPY; SYNTHESIS; THERAPY; TOMOGRAPHY; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Mease, R C, Mausner, L F, and Srivastava, S C. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging. United States: N. p., 1994.
Web.
Mease, R C, Mausner, L F, & Srivastava, S C. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging. United States.
Mease, R C, Mausner, L F, and Srivastava, S C. 1994.
"Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging". United States.
@article{osti_5043183,
title = {Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging},
author = {Mease, R C and Mausner, L F and Srivastava, S C},
abstractNote = {Cyclo agents are described which are useful in forming antibody-metal conjugates which are used for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2diamino cyclohexane-N,N,N',N'-tetra acetic acid. No Drawings},
doi = {},
url = {https://www.osti.gov/biblio/5043183},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 08 00:00:00 EST 1994},
month = {Tue Mar 08 00:00:00 EST 1994}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.