Guinea pig MHC: functional significance and structural characterization
Conference
·
· Cold Spring Harbor Symp. Quant. Biol.; (United States)
OSTI ID:5040127
Over the past several years, we have utilized a combination of serologic, chemical, and functional studies in both inbred and outbred animals which have allowed us to identify genes within the GPLA complex that encode histocompatibility antigens, Ia antigens, and immune response function. This paper reports a summary of those studies. Our results indicate that the GPLA complex is homologous to the murine H-2 and human HL-A complexes, and that the guinea pig I region contains at least three subregions, each of which encodes an Ia antigen with a characteristic molecular structure.
- Research Organization:
- National Inst. of Allergy and Infectious Diseases, Bethesda, MD
- OSTI ID:
- 5040127
- Journal Information:
- Cold Spring Harbor Symp. Quant. Biol.; (United States), Vol. 41; Conference: Cold Spring Harbor symposium on quantitative biology, Cold Spring Harbor, NY, USA, Jun 1976
- Country of Publication:
- United States
- Language:
- English
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