Biochemical and morphological changes in the epithelial cells of the small intestine after irradiation
Rats have been sacrificed after abdominal irradiation with sublethal doses at very close intervals. Observation at light and electron microscope have been carried out on the small intestine of these animals in order to try to explain the simultaneous modifications of leucineaminopeptidase (LAP) activity. In connection with the increase of LAP activity no modifications have been evidenced, at the light microscope, in the differentiated cells of the villus where the membrane digestion process takes place. In the crypt-villus junction we observe at the electron microscope a remarkable increase in the number of ribosomes since the early intervals. Also during the return phase to normal activities the cells of the crypt and of the crypt-villus junction show a temporaneous increase in the amount of ribosomes. Shortly afterwards we observe an increase of LAP activity.
- Research Organization:
- Univ., Florence
- OSTI ID:
- 5038462
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 1:No. 9-10
- Country of Publication:
- United States
- Language:
- English
Similar Records
Alkaline phosphatase in the intestine of the mouse during radioinduced atropy of the villi
Late effects in the mouse small intestine after a clinically relevant multifractionated radiation treatment
Related Subjects
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
CATALYSIS
CELL CONSTITUENTS
ENZYMES
EPITHELIUM
IRRADIATION
METABOLISM
MORPHOLOGICAL CHANGES
RADIATION DOSES
RATS
RIBOSOMES
SMALL INTESTINE
ANIMALS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DOSES
GASTROINTESTINAL TRACT
INTESTINES
MAMMALS
ORGANOIDS
ORGANS
RADIATION EFFECTS
RODENTS
TISSUES
VERTEBRATES
560150* - Radiation Effects on Animals