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Title: Method to directly radiolabel antibodies for diagnostic imaging and therapy

Patent ·
OSTI ID:5026117

This patent describes a method for directly labeling proteins with radionuclides for use in diagnostic imaging and therapy. It comprises: the steps of incubating a protein-containing solution with a solution of sodium ascorbate; adding a required quantity of reduced radionuclide to the incubated protein-containing solution and incubating.

Assignee:
Thomas Jefferson Univ., Philadelphia, PA (USA)
Patent Number(s):
US 5011676; A
Application Number:
PPN: US 7-499790
OSTI ID:
5026117
Resource Relation:
Patent File Date: 27 Mar 1990
Country of Publication:
United States
Language:
English

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
LABELLING
IMAGE PROCESSING
DIAGNOSTIC USES
LABELLED COMPOUNDS
RADIOIMMUNOTHERAPY
IMMUNOLOGY
IMMUNOTHERAPY
MEDICINE
NUCLEAR MEDICINE
PROCESSING
RADIOIMMUNOLOGY
RADIOLOGY
RADIOTHERAPY
THERAPY
USES
550201* - Biochemistry- Tracer Techniques
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production
550601 - Medicine- Unsealed Radionuclides in Diagnostics
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)