skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Further studies on the mechanism of radiation induced thymic lymphoma prevention by bone marrow transplantation in C57BL mice

Abstract

Whole body fractionated irradiation induces thymic lymphomas in C57BL/Ka mice after a latent period during which intrathymic lymphopoiesis is modified; thymocyte numbers are subnormal and the epithelial component of thymic nurse cells (TNCs) is altered as estimated by the number of TNCs in vivo and by its ability to interact with immature thymocytes in vitro. A graft of normal bone marrow cells immediately after the last irradiation prevents the development of lymphomas; but when such a graft is performed 1 month later, it does not inhibit the emergence of tumors. In both cases the grafted precursors home and repopulate the thymus. However, the delayed graft does not exert any effect upon the altered epithelial component of TNCs, whereas the early one restores the numbers of TNCs and the function of their epithelial component. The results thus demonstrate that lymphoid thymic repopulation by a bone marrow graft is not sufficient to prevent the development of lymphomas and that there is an intimate relationship between tumor development and alterations of nurse cells microenvironment.

Authors:
; ; ; ;  [1]
  1. (University Hospital, Liege (Belgium))
Publication Date:
OSTI Identifier:
5022537
Resource Type:
Journal Article
Journal Name:
Leukemia; (USA)
Additional Journal Information:
Journal Volume: 3:11; Journal ID: ISSN 0887-6924
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW; TRANSPLANTS; LYMPHOMAS; RADIOINDUCTION; THYMUS; EPITHELIUM; EXPERIMENTAL NEOPLASMS; FRACTIONATED IRRADIATION; MICE; THYMOCYTES; WHOLE-BODY IRRADIATION; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; BODY; DISEASES; EXTERNAL IRRADIATION; HEMATOPOIETIC SYSTEM; IMMUNE SYSTEM DISEASES; IRRADIATION; LYMPHATIC SYSTEM; MAMMALS; NEOPLASMS; ORGANS; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Humblet, C., Defresne, M.P., Greimers, R., Rongy, A.M., and Boniver, J. Further studies on the mechanism of radiation induced thymic lymphoma prevention by bone marrow transplantation in C57BL mice. United States: N. p., 1989. Web.
Humblet, C., Defresne, M.P., Greimers, R., Rongy, A.M., & Boniver, J. Further studies on the mechanism of radiation induced thymic lymphoma prevention by bone marrow transplantation in C57BL mice. United States.
Humblet, C., Defresne, M.P., Greimers, R., Rongy, A.M., and Boniver, J. Wed . "Further studies on the mechanism of radiation induced thymic lymphoma prevention by bone marrow transplantation in C57BL mice". United States.
@article{osti_5022537,
title = {Further studies on the mechanism of radiation induced thymic lymphoma prevention by bone marrow transplantation in C57BL mice},
author = {Humblet, C. and Defresne, M.P. and Greimers, R. and Rongy, A.M. and Boniver, J.},
abstractNote = {Whole body fractionated irradiation induces thymic lymphomas in C57BL/Ka mice after a latent period during which intrathymic lymphopoiesis is modified; thymocyte numbers are subnormal and the epithelial component of thymic nurse cells (TNCs) is altered as estimated by the number of TNCs in vivo and by its ability to interact with immature thymocytes in vitro. A graft of normal bone marrow cells immediately after the last irradiation prevents the development of lymphomas; but when such a graft is performed 1 month later, it does not inhibit the emergence of tumors. In both cases the grafted precursors home and repopulate the thymus. However, the delayed graft does not exert any effect upon the altered epithelial component of TNCs, whereas the early one restores the numbers of TNCs and the function of their epithelial component. The results thus demonstrate that lymphoid thymic repopulation by a bone marrow graft is not sufficient to prevent the development of lymphomas and that there is an intimate relationship between tumor development and alterations of nurse cells microenvironment.},
doi = {},
journal = {Leukemia; (USA)},
issn = {0887-6924},
number = ,
volume = 3:11,
place = {United States},
year = {1989},
month = {11}
}