Effective multimodality treatment for advanced epidermoid carcinoma of the female genital tract

Journal Article · Mon Jul 01 00:00:00 EDT 1985 · J. Clin. Oncol.; (United States)

OSTI ID:5019018

Kalra, J; Cortes, E; Chen, S; Krumholz, B; Rovinsky, J J; Molho, L; Seltzer, V; Papantoniou, P; Lee, J Y

Fifteen patients with advanced or recurrent squamous-cell carcinoma of the cervix, vulva, vagina, and urethra were treated with simultaneous combination chemotherapy (5-fluorouracil infusion and mitomycin C) and radiotherapy (3,000 rad for a period of three weeks). Three to four weeks after completion of radiotherapy, 13 of 15 patients achieved partial or complete tumor shrinkage. Nine of 15 patients are alive, eight of whom (at a median follow-up time of 24 months) have no evidence of disease. The longest survival time was 45 + months. There was minimal toxicity associated with this therapy. The results of this pilot study suggest that the simultaneous administration of radiation and chemotherapy is an effective method of treatment of advanced female genital tract carcinoma.

• Research Organization: Long Island Jewish-Hillside Medical Center, New Hyde Park, NY
• OSTI ID: 5019018
• Journal Information: J. Clin. Oncol.; (United States), Vol. 7
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
CHEMOTHERAPY
RADIOTHERAPY
FEMALE GENITALS
FLUOROURACILS
MITOMYCIN
PATIENTS
RADIATION DOSES
SURVIVAL TIME
SYNERGISM
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZINES
BODY
DISEASES
DOSES
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIOLOGY
THERAPY
URACILS
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine