skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q

Abstract

Metabotropic glutamate receptors (GRMs) are neutrotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome 7q21.1-q21.2 and 7q31.3-q32.1, respectively, using somatic cell hybrid and fluorescence in situ hybridization analysis. A yeast artificial chromosome contig was constructed surrounding the genes, allowing their location to be integrated into the genetic and physical map of chromosome 7. 20 refs., 2 figs.

Authors:
; ;  [1]
  1. Hospital for Sick Children, Ontario (Canada) [and others
Publication Date:
OSTI Identifier:
501821
Resource Type:
Journal Article
Resource Relation:
Journal Name: Genomics; Journal Volume: 31; Journal Issue: 2; Other Information: PBD: 15 Jan 1996
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; HUMAN CHROMOSOME 7; GENETIC MAPPING; CHROMOSOMAL ABERRATIONS; STRUCTURE-ACTIVITY RELATIONSHIPS; CONTIGS; DESIGN; RECEPTORS; DNA SEQUENCING; DNA-CLONING; MAN; HEREDITARY DISEASES; NERVOUS SYSTEM DISEASES; SENSE ORGANS DISEASES; SOMATIC CELLS; HYBRIDIZATION; DNA HYBRIDIZATION; FLUORESCENCE; POLYMERASE CHAIN REACTION; BIOLOGICAL MARKERS

Citation Formats

Scherer, S.W., Heng, H.H.Q., and Lap-Chee Tsui. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. United States: N. p., 1996. Web. doi:10.1006/geno.1996.0036.
Scherer, S.W., Heng, H.H.Q., & Lap-Chee Tsui. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. United States. doi:10.1006/geno.1996.0036.
Scherer, S.W., Heng, H.H.Q., and Lap-Chee Tsui. Mon . "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". United States. doi:10.1006/geno.1996.0036.
@article{osti_501821,
title = {Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q},
author = {Scherer, S.W. and Heng, H.H.Q. and Lap-Chee Tsui},
abstractNote = {Metabotropic glutamate receptors (GRMs) are neutrotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome 7q21.1-q21.2 and 7q31.3-q32.1, respectively, using somatic cell hybrid and fluorescence in situ hybridization analysis. A yeast artificial chromosome contig was constructed surrounding the genes, allowing their location to be integrated into the genetic and physical map of chromosome 7. 20 refs., 2 figs.},
doi = {10.1006/geno.1996.0036},
journal = {Genomics},
number = 2,
volume = 31,
place = {United States},
year = {Mon Jan 15 00:00:00 EST 1996},
month = {Mon Jan 15 00:00:00 EST 1996}
}