Benzene-induced micronuclei formation in mouse fetal liver blood, peripheral blood, and maternal bone marrow cells

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Environmental Management; (United States)

DOI:https://doi.org/10.1002/em.2850180102· OSTI ID:5011012

Ning, Hansun ^[1]; Kado, N Y ^[2]; Kuzmicky, P A; Hsieh, D P.H. ^[3]

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1. Univ. of California, Davis (United States) Ministry of Railways, Beijing (China)
2. Univ. of California, Davis (United States) California Air Resources Board, Sacramento (United States)
3. Univ. of California, Davis (United States)

The transplacental cytogenetic effects of benzene were studied by using the micronucleus test of polychromatic erythrocytes (PCE) found in both fetal liver and fetal peripheral blood, and were compared with PCE from maternal bone marrow. Timed-pregnant mice received single intraperitoneal doses of benzene on the 14th day of gestation and were sacrificed 21 hours after injection. Benzene elicited a significant increase in the frequency of micronucleated polychromatic erythrocytes (MNPCE) in fetal liver blood cells at doses of 219 to 874 mg/kg, and in fetal peripheral blood cells and maternal bone marrow cells at doses of 437 and 874 mg/kg. The data demonstrate that benzene is a moderate transplacental clastogenic agent, and that the mouse transplacental micronucleus test using fetal liver blood cells is a potentially more sensitive indicator of the genotoxicity of benzene than either fetal peripheral blood or maternal bone marrow cells.

• OSTI ID: 5011012
• Journal Information: Environmental Management; (United States), Vol. 18:1; ISSN 0364-152X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZENE
PRENATAL EXPOSURE
ERYTHROCYTES
CYTOCHEMISTRY
BONE MARROW CELLS
CELL NUCLEI
FETUSES
GENETIC EFFECTS
LIVER
MICE
PLACENTA
PREGNANCY
ANIMAL CELLS
ANIMALS
AROMATICS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL CONSTITUENTS
CHEMISTRY
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
FETAL MEMBRANES
GLANDS
HYDROCARBONS
MAMMALS
MATERIALS
MEMBRANES
ORGANIC COMPOUNDS
ORGANS
RODENTS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology