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Title: Benign and malignant thyroid nodules after neck irradiation

Abstract

A total of 444 persons were examined for the presence of thyroid nodules on average of 43 years after having been treated with x-rays for cervical tuberculous adenitis. Of this total, 101 subjects had undergone surgery for thyroid nodules: 25 for carcinoma (6%) and 76 for benign nodules (17%). Carcinoma occurred with the same frequency in multinodular and uninodular glands. Because of the uneven age distribution in the current series, it could not be decided whether there was a higher susceptibility of the young thyroid to the induction of thyroid carcinoma or benign nodules. The dosage range for the whole series was 0.40 to 50.90 Gy (40-5090 rad). There was a positive correlation between the absorbed radiation dose and the probability of developing benign and malignant thyroid nodules, even after doses of 20 Gy or more. The risk of developing thyroid carcinoma was equal for men and women, while the female-to-male ratio for benign nodules was 2.9:1, indicating that risk factors associated with females are of less importance in irradiated than in nonirradiated populations. The median latency for carcinoma was 40 years, suggesting that the increased risk of thyroid carcinoma after irradiation remains for the rest of the patient's life.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Univ. of Goeteborg, Sweden
OSTI Identifier:
5005440
Resource Type:
Journal Article
Journal Name:
Cancer (Philadelphia); (United States)
Additional Journal Information:
Journal Volume: 6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOTHERAPY; SIDE EFFECTS; THYROID; DELAYED RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; NECK; PATIENTS; X RADIATION; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; BODY AREAS; ELECTROMAGNETIC RADIATION; ENDOCRINE GLANDS; GLANDS; IONIZING RADIATIONS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Fjaelling, M.T., Tisell, L.E., Carlsson, S., Hansson, G., Lundberg, L.M., and Oden, A. Benign and malignant thyroid nodules after neck irradiation. United States: N. p., 1986. Web. doi:10.1002/1097-0142(19860915)58:6<1219::AID-CNCR2820580608>3.0.CO;2-S.
Fjaelling, M.T., Tisell, L.E., Carlsson, S., Hansson, G., Lundberg, L.M., & Oden, A. Benign and malignant thyroid nodules after neck irradiation. United States. doi:10.1002/1097-0142(19860915)58:6<1219::AID-CNCR2820580608>3.0.CO;2-S.
Fjaelling, M.T., Tisell, L.E., Carlsson, S., Hansson, G., Lundberg, L.M., and Oden, A. Mon . "Benign and malignant thyroid nodules after neck irradiation". United States. doi:10.1002/1097-0142(19860915)58:6<1219::AID-CNCR2820580608>3.0.CO;2-S.
@article{osti_5005440,
title = {Benign and malignant thyroid nodules after neck irradiation},
author = {Fjaelling, M.T. and Tisell, L.E. and Carlsson, S. and Hansson, G. and Lundberg, L.M. and Oden, A.},
abstractNote = {A total of 444 persons were examined for the presence of thyroid nodules on average of 43 years after having been treated with x-rays for cervical tuberculous adenitis. Of this total, 101 subjects had undergone surgery for thyroid nodules: 25 for carcinoma (6%) and 76 for benign nodules (17%). Carcinoma occurred with the same frequency in multinodular and uninodular glands. Because of the uneven age distribution in the current series, it could not be decided whether there was a higher susceptibility of the young thyroid to the induction of thyroid carcinoma or benign nodules. The dosage range for the whole series was 0.40 to 50.90 Gy (40-5090 rad). There was a positive correlation between the absorbed radiation dose and the probability of developing benign and malignant thyroid nodules, even after doses of 20 Gy or more. The risk of developing thyroid carcinoma was equal for men and women, while the female-to-male ratio for benign nodules was 2.9:1, indicating that risk factors associated with females are of less importance in irradiated than in nonirradiated populations. The median latency for carcinoma was 40 years, suggesting that the increased risk of thyroid carcinoma after irradiation remains for the rest of the patient's life.},
doi = {10.1002/1097-0142(19860915)58:6<1219::AID-CNCR2820580608>3.0.CO;2-S},
journal = {Cancer (Philadelphia); (United States)},
number = ,
volume = 6,
place = {United States},
year = {1986},
month = {9}
}