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Title: Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 1. Subchronic exposure to arsenate utilizing constant rate administration

Abstract

The concentration, availability, and chemical status of radiolabeled arsenic has been determined in the blood of pregnant hamsters at the beginning (morning of Day 8) and the end (morning of Day 9) of the critical period of embryogenesis. Hamster dams were exposed to teratogenic doses of arsenate by means of osmotic minipumps implanted on the morning of Day 6 of the gestation period. Whole blood arsenic concentrations were the same for 48 and 72 hr postimplant. The arsenic concentration of plasma equaled that of red cells. Plasma arsenic was not bound to macromolecules and had the same chemical status 48 and 72 hr postimplant. Arsenate was the dominant form (67% of the total). However, the presence of dimethylarsinic acid and arsenite indicates that the pentavalent species was metabolized. Red cell arsenic was bound to macromolecules in the cell sap. Seventy percent of red cell sap arsenic was dialyzable 48 hr postimplant, but only 56% 72 hr postimplant. Arsenate was the dominant dialyzable red cell species on Day 8 and arsenite was the major dialyzable form on Day 9. The authors findings demonstrate a relationship between the maternal blood concentration and chemical status of arsenic and the presence of malformations resultingmore » from a constant rate exposure of pregnant hamsters to arsenate via the osmotic minipump.« less

Authors:
;
Publication Date:
Research Org.:
Dartmouth Medical School, Hanover, NH
OSTI Identifier:
5001882
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 40:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ARSENIC; BIOLOGICAL AVAILABILITY; BLOOD CHEMISTRY; CHEMICAL STATE; METABOLISM; TERATOGEN SCREENING; BLOOD; BLOOD PLASMA; ERYTHROCYTES; EXPERIMENTAL DATA; HAMSTERS; ONTOGENESIS; PREGNANCY; TERATOGENESIS; TRACER TECHNIQUES; ANIMALS; BIOLOGICAL MATERIALS; BLOOD CELLS; BODY FLUIDS; DATA; ELEMENTS; INFORMATION; ISOTOPE APPLICATIONS; MAMMALS; MATERIALS; NUMERICAL DATA; RODENTS; SCREENING; SEMIMETALS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550501 - Metabolism- Tracer Techniques

Citation Formats

Hanlon, D.P., and Ferm, V.H. Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 1. Subchronic exposure to arsenate utilizing constant rate administration. United States: N. p., 1986. Web.
Hanlon, D.P., & Ferm, V.H. Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 1. Subchronic exposure to arsenate utilizing constant rate administration. United States.
Hanlon, D.P., and Ferm, V.H. Fri . "Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 1. Subchronic exposure to arsenate utilizing constant rate administration". United States.
@article{osti_5001882,
title = {Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 1. Subchronic exposure to arsenate utilizing constant rate administration},
author = {Hanlon, D.P. and Ferm, V.H.},
abstractNote = {The concentration, availability, and chemical status of radiolabeled arsenic has been determined in the blood of pregnant hamsters at the beginning (morning of Day 8) and the end (morning of Day 9) of the critical period of embryogenesis. Hamster dams were exposed to teratogenic doses of arsenate by means of osmotic minipumps implanted on the morning of Day 6 of the gestation period. Whole blood arsenic concentrations were the same for 48 and 72 hr postimplant. The arsenic concentration of plasma equaled that of red cells. Plasma arsenic was not bound to macromolecules and had the same chemical status 48 and 72 hr postimplant. Arsenate was the dominant form (67% of the total). However, the presence of dimethylarsinic acid and arsenite indicates that the pentavalent species was metabolized. Red cell arsenic was bound to macromolecules in the cell sap. Seventy percent of red cell sap arsenic was dialyzable 48 hr postimplant, but only 56% 72 hr postimplant. Arsenate was the dominant dialyzable red cell species on Day 8 and arsenite was the major dialyzable form on Day 9. The authors findings demonstrate a relationship between the maternal blood concentration and chemical status of arsenic and the presence of malformations resulting from a constant rate exposure of pregnant hamsters to arsenate via the osmotic minipump.},
doi = {},
journal = {Environ. Res.; (United States)},
number = ,
volume = 40:2,
place = {United States},
year = {1986},
month = {8}
}