Risk analysis of multiple environmental factors: radiation, zinc, cadmium, and calcium
Simultaneous effects of four risk factors, i.e., radiation exposure at a sublethal dose and excessive administration of zinc or cadmium and calcium deprivation, were examined by animal experiments. Deaths among 360 mice within 30 days after the whole body irradiation of 524-617 rad gamma rays were observed under 36 experimental conditions set by all possible combinations of varied levels of the four risk factors. A similar experiment was conducted a month later to check the reproducibility by using another 360 mice. The reproducibility of the experiment was confirmed and therefore the data from the two experiments were pooled. The analysis of data based on a multiple logistic model suggested that administration of zinc acts protectively against radiation.
- Research Organization:
- Univ. of Tokyo, Japan
- OSTI ID:
- 5001281
- Journal Information:
- Environ. Res.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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MICE
WHOLE-BODY IRRADIATION
ZINC
RADIOSENSITIVITY EFFECTS
CADMIUM
CALCIUM
GAMMA RADIATION
INTESTINES
SUBLETHAL IRRADIATION
ALKALINE EARTH METALS
ANIMALS
BODY
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ELEMENTS
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
IONIZING RADIATIONS
IRRADIATION
MAMMALS
METALS
ORGANS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)