Effect of low-level copper and pentachlorophenol exposure on various early life stages of Xenopus laevis
- The Stover Group, Stillwater, OK (United States)
An evaluation of the effects of low-level copper and pentachlorophenol exposure on various early life stages of the South African clawed frog, Xenopus laevis, was performed using stage-specific and long-term continuous exposures. Stage-specific exposure experiments were conducted such that separate subsets of embryos and larvae from the same clutch were exposed to two toxicants, copper and pentachlorphenol, from 0 d to 4 d (standard Frog Embryo Teratogenesis Assay--Xenopus [FETAX]), 4 d to 8 d, 8 d to 12 d, and 12 d to 16 d. Results from two separate concentration-response experiments indicated that sensitivity to either toxicant increased in each successive time period. Longer-term exposure studies conducted for 60 to 75 days indicated that copper, but not pentachlorophenol induced reduction deficiency malformations of the hind limb at concentrations as low as 0.05 mg/L. Pentachlorophenol concentrations as low as 0.5 {micro}g/L inhibited tail resorption. However, copper did not adversely affect the process of tail resorption. These results indicated that studies evaluating longer-term developmental processes are important in ecological hazard evaluation.
- OSTI ID:
- 495382
- Report Number(s):
- CONF-9504216-; TRN: IM9731%%75
- Resource Relation:
- Conference: 5. Environmental toxicology and risk assessment: biomarkers and risk assessment, Denver, CO (United States), 2-7 Apr 1995; Other Information: PBD: 1996; Related Information: Is Part Of Environmental toxicology and risk assessment: Biomarkers and risk assessment. Volume 5; Bengtson, D.A.; Henshel, D.S. [eds.]; PB: [485] p.; ASTM special technical publication, 1306
- Country of Publication:
- United States
- Language:
- English
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