The inhibition of DNA synthesis by calf-thymus polymerase by X-irradiation of the primer DNA
Abstract
Studies were made to determine whether or not DNA damaged by x irradiation may be easily replicated by the DNA synthetic mechanism. It was found that the synthesis of new material is strongly inhibited by large doses of x rays, and that within the experimental error, there is no great difference in the amounts of incorporation of d-TMP and d-CMP at any dose level that was examined. The results emphasize that the system used for assaying the effects of irradiation may greatly modify the results obtained.
- Authors:
- Publication Date:
- Research Org.:
- Yale Univ., New Haven
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 4843061
- NSA Number:
- NSA-15-029014
- Resource Type:
- Journal Article
- Journal Name:
- Biochemical and Biophysical Research Communications
- Additional Journal Information:
- Journal Volume: 5; Journal Issue: 6; Other Information: Orig. Receipt Date: 31-DEC-61; Journal ID: ISSN 0006-291X
- Publisher:
- Elsevier
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
- Subject:
- BIOLOGY AND MEDICINE; ANIMALS; BIOSYNTHESIS; ENZYMES; NUCLEIC ACIDS; RADIATION DOSES; THYMUS; X RADIATION
Citation Formats
Stacey, K. A. The inhibition of DNA synthesis by calf-thymus polymerase by X-irradiation of the primer DNA. Country unknown/Code not available: N. p., 1961.
Web. doi:10.1016/0006-291X(61)90101-2.
Stacey, K. A. The inhibition of DNA synthesis by calf-thymus polymerase by X-irradiation of the primer DNA. Country unknown/Code not available. https://doi.org/10.1016/0006-291X(61)90101-2
Stacey, K. A. 1961.
"The inhibition of DNA synthesis by calf-thymus polymerase by X-irradiation of the primer DNA". Country unknown/Code not available. https://doi.org/10.1016/0006-291X(61)90101-2.
@article{osti_4843061,
title = {The inhibition of DNA synthesis by calf-thymus polymerase by X-irradiation of the primer DNA},
author = {Stacey, K. A.},
abstractNote = {Studies were made to determine whether or not DNA damaged by x irradiation may be easily replicated by the DNA synthetic mechanism. It was found that the synthesis of new material is strongly inhibited by large doses of x rays, and that within the experimental error, there is no great difference in the amounts of incorporation of d-TMP and d-CMP at any dose level that was examined. The results emphasize that the system used for assaying the effects of irradiation may greatly modify the results obtained.},
doi = {10.1016/0006-291X(61)90101-2},
url = {https://www.osti.gov/biblio/4843061},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 6,
volume = 5,
place = {Country unknown/Code not available},
year = {Fri Sep 01 00:00:00 EDT 1961},
month = {Fri Sep 01 00:00:00 EDT 1961}
}
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